EC number:1.14.19.50
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.50 |
|---|---|
| Description: | Noroxomaritidine synthase. |
| Alternative Name: |
CYP96T1. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.50 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.50 |
| KEGG Enzyme Link: | KEGG1.14.19.50 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.50 |
| ExPASy Enzyme Link: | ExPASy1.14.19.50 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.50 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.50 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.50 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.50 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.50 |
EC number:1.14.19.50
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:51264 | 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]:[cH;+0:12]:[*:13]-[*:14]-[NH;+0:15]-[*:16]-[*:17]-[c;H0;+0:18]1:[cH;+0:19]:[cH;+0:20]:[c;H0;+0:21](-[OH;+0:22]):[cH;+0:23]:[cH;+0:24]:1.[O;H0;+0:25]=[O;H0;+0:26]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]:[c;H0;+0:12]1:[*:13]-[*:14]-[N;H0;+0:15]2-[*:16]-[*:17]-[C;H0;+0:18]-13-[CH;+0:24]=[CH;+0:23]-[C;H0;+0:21](=[O;H0;+0:22])-[CH2;+0:20]-[CH;+0:19]-2-3.[OH2;+0:25].[OH2;+0:26] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| CYP96T1 of Narcissus sp. aff. pseudonarcissus Catalyzes Formation of the Para-Para' C-C Phenol Couple in the Amaryllidaceae Alkaloids. | Kilgore MB, Augustin MM, May GD, Crow JA, Kutchan TM | 2016 | 26941773 |
| RHEA:51260 | 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]:[cH;+0:12]:[*:13]-[*:14]-[NH;+0:15]-[*:16]-[*:17]-[c;H0;+0:18]1:[cH;+0:19]:[cH;+0:20]:[c;H0;+0:21](-[OH;+0:22]):[cH;+0:23]:[cH;+0:24]:1.[O;H0;+0:25]=[O;H0;+0:26]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]:[c;H0;+0:12]1:[*:13]-[*:14]-[N;H0;+0:15]2-[*:16]-[*:17]-[C;H0;+0:18]-13-[CH;+0:24]=[CH;+0:23]-[C;H0;+0:21](=[O;H0;+0:22])-[CH2;+0:20]-[CH;+0:19]-2-3.[OH2;+0:25].[OH2;+0:26] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| CYP96T1 of Narcissus sp. aff. pseudonarcissus Catalyzes Formation of the Para-Para' C-C Phenol Couple in the Amaryllidaceae Alkaloids. | Kilgore MB, Augustin MM, May GD, Crow JA, Kutchan TM | 2016 | 26941773 |