EC number:1.14.19.54
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.54 |
|---|---|
| Description: | 1,2-dehydroreticuline synthase. |
| Alternative Name: |
CYP82Y2. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.54 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.54 |
| KEGG Enzyme Link: | KEGG1.14.19.54 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.54 |
| ExPASy Enzyme Link: | ExPASy1.14.19.54 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.54 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.54 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.54 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.54 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.54 |
EC number:1.14.19.54
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:56308 | (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[N;H0;+0:4](-[*:5])-[*:6].[*:7]-[N;H0;+0:8]1-[*:9]:[*:10]-[NH;+0:11]-[c;H0;+0:12](:[*:13]):[c;H0;+0:14]-1:[nH;+0:15]:[*:16].[O;H0;+0:17]=[O;H0;+0:18]>>[*:1]-[C;H0;+0:2](-[*:3])=[N+;H0:4](-[*:5])-[*:6].[*:7]-[n;H0;+0:8]1:[*:9]:[*:10]:[n;H0;+0:11]:[c;H0;+0:12](:[*:13])-[c;H0;+0:14]:1:[n;H0;+0:15]:[*:16].[OH2;+0:17].[OH2;+0:18] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy. | Farrow SC, Hagel JM, Beaudoin GA, Burns DC, Facchini PJ | 2015 Sep | 26147354 |
| Plant science. Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein. | Winzer T, Kern M, King AJ, Larson TR, Teodor RI, Donninger SL, Li Y, Dowle AA, Cartwright J, Bates R, Ashford D, Thomas J, Walker C, Bowser TA, Graham IA | 2015 Jul 17 | 26113639 |
| 1,2-Dehydroreticuline synthase, the branch point enzyme opening the morphinan biosynthetic pathway. | Hirata K, Poeaknapo C, Schmidt J, Zenk MH | 2004 Apr | 15110683 |