EC number:1.14.19.55
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.55 |
|---|---|
| Description: | 4-hydroxybenzoate brominase (decarboxylating). |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.55 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.55 |
| KEGG Enzyme Link: | KEGG1.14.19.55 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.55 |
| ExPASy Enzyme Link: | ExPASy1.14.19.55 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.55 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.55 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.55 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.55 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.55 |
EC number:1.14.19.55
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:56368 | 3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[C;H0;+0:12](-[*:13])-[CH2;+0:14]-[CH;+0:15]=[CH;+0:16]-1.[*:17]:[cH;+0:18]:[*:19]:[c;H0;+0:20](:[*:21])-[C;H0;+0:22](=[*:23])-[OH;+0:24].[Br-;H0:25].[Br-;H0:26].[H+;H0:27].[H+;H0:28].[H+;H0:29].[H+;H0:30].[H+;H0:31].[O;H0;+0:32]=[O;H0;+0:33].[O;H0;+0:34]=[O;H0;+0:35]>>[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]-[n+;H0:10]1:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:1.[*:17]:[c;H0;+0:18](-[Br;H0;+0:26]):[*:19]:[c;H0;+0:20](:[*:21])-[Br;H0;+0:25].[*:23]=[C;H0;+0:22]=[O;H0;+0:24].[OH2;+0:32].[OH2;+0:33].[OH2;+0:34].[OH2;+0:35] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymatic synthesis of polybrominated dioxins from the marine environment. | Agarwal V, Moore BS | 2014 Sep 19 | 25061970 |
| Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. | Agarwal V, El Gamal AA, Yamanaka K, Poth D, Kersten RD, Schorn M, Allen EE, Moore BS | 2014 Aug | 24974229 |
| RHEA:56348 | 4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[C;H0;+0:12](-[*:13])-[CH2;+0:14]-[CH;+0:15]=[CH;+0:16]-1.[*:17]:[c;H0;+0:18](:[*:19]:[cH;+0:20]:[*:21])-[C;H0;+0:22](=[*:23])-[OH;+0:24].[Br-;H0:25].[Br-;H0:26].[H+;H0:27].[H+;H0:28].[H+;H0:29].[H+;H0:30].[H+;H0:31].[O;H0;+0:32]=[O;H0;+0:33].[O;H0;+0:34]=[O;H0;+0:35]>>[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]-[n+;H0:10]1:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:1.[*:17]:[c;H0;+0:18](-[Br;H0;+0:25]):[*:19]:[c;H0;+0:20](:[*:21])-[Br;H0;+0:26].[*:23]=[C;H0;+0:22]=[O;H0;+0:24].[OH2;+0:32].[OH2;+0:33].[OH2;+0:34].[OH2;+0:35] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymatic synthesis of polybrominated dioxins from the marine environment. | Agarwal V, Moore BS | 2014 Sep 19 | 25061970 |
| Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. | Agarwal V, El Gamal AA, Yamanaka K, Poth D, Kersten RD, Schorn M, Allen EE, Moore BS | 2014 Aug | 24974229 |