EC number:1.14.19.56
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.56 |
|---|---|
| Description: | 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.56 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.56 |
| KEGG Enzyme Link: | KEGG1.14.19.56 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.56 |
| ExPASy Enzyme Link: | ExPASy1.14.19.56 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.56 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.56 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.56 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.56 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.56 |
EC number:1.14.19.56
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:56380 | (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]:[cH;+0:12]:[cH;+0:13]:[*:14].[*:15]:[nH;+0:16]:[c;H0;+0:17]1:[c;H0;+0:18](:[*:19])-[NH;+0:20]-[*:21]:[*:22]-[N;H0;+0:23]-1-[*:24].[Cl-;H0:25].[Cl-;H0:26].[O;H0;+0:27]=[O;H0;+0:28].[O;H0;+0:29]=[O;H0;+0:30]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]:[c;H0;+0:12](-[Cl;H0;+0:25]):[c;H0;+0:13](:[*:14])-[Cl;H0;+0:26].[*:15]:[n;H0;+0:16]:[c;H0;+0:17]1:[n;H0;+0:23](-[*:24]):[*:22]:[*:21]:[n;H0;+0:20]:[c;H0;+0:18]-1:[*:19].[OH2;+0:27].[OH2;+0:28].[OH2;+0:29].[OH2;+0:30] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of halogenase PltA from the pyoluteorin biosynthetic pathway. | Pang AH, Garneau-Tsodikova S, Tsodikov OV | 2015 Dec | 26416533 |
| Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. | Dorrestein PC, Yeh E, Garneau-Tsodikova S, Kelleher NL, Walsh CT | 2005 Sep 27 | 16162666 |
| Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. | Nowak-Thompson B, Chaney N, Wing JS, Gould SJ, Loper JE | 1999 Apr | 10094695 |