EC number:1.14.19.58

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
ID:1.14.19.58
Description:Tryptophan 5-halogenase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.19.58
BRENDA Enzyme Link: BRENDA 1.14.19.58
KEGG Enzyme Link: KEGG1.14.19.58
BioCyc Enzyme Link: BioCyc 1.14.19.58
ExPASy Enzyme Link: ExPASy1.14.19.58
EC2PDB Enzyme Link: EC2PDB 1.14.19.58
ExplorEnz Enzyme Link: ExplorEnz 1.14.19.58
PRIAM enzyme-specific profiles Link: PRIAM 1.14.19.58
IntEnz Enzyme Link: IntEnz 1.14.19.58
MEDLINE Enzyme Link: MEDLINE 1.14.19.58

EC number:1.14.19.58

MSA:

1.14.19.58;
Phylogenetic Tree:

1.14.19.58;
Uniprot:
M-CSA:
RHEA:55896 chloride + FADH2 + L-tryptophan + O2 = 5-chloro-L-tryptophan + FAD + 2 H2O
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]:[cH;+0:12]:[*:13].[Cl-;H0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]:[c;H0;+0:12](:[*:13])-[Cl;H0;+0:14].[OH2;+0:15].[OH2;+0:16]
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References

TitleAuthorsDatePubMed ID
Structural insights into regioselectivity in the enzymatic chlorination of tryptophan.Zhu X, De Laurentis W, Leang K, Herrmann J, Ihlefeld K, van Pée KH, Naismith JH2009 Aug 719501593
A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005.Zehner S, Kotzsch A, Bister B, Süssmuth RD, Méndez C, Salas JA, van Pée KH2005 Apr15850981