EC number:1.14.19.59
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.59 |
|---|---|
| Description: | Tryptophan 6-halogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.59 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.59 |
| KEGG Enzyme Link: | KEGG1.14.19.59 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.59 |
| ExPASy Enzyme Link: | ExPASy1.14.19.59 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.59 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.59 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.59 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.59 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.59 |
EC number:1.14.19.59
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:56528 | chloride + D-tryptophan + FADH2 + O2 = 6-chloro-D-tryptophan + FAD + 2 H2O |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]:[cH;+0:12]:[*:13].[Cl-;H0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]:[c;H0;+0:12](:[*:13])-[Cl;H0;+0:14].[OH2;+0:15].[OH2;+0:16] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase. | Shepherd SA, Menon BR, Fisk H, Struck AW, Levy C, Leys D, Micklefield J | 2016 May 3 | 26840773 |
| A tryptophan 6-halogenase and an amidotransferase are involved in thienodolin biosynthesis. | Milbredt D, Patallo EP, van Pée KH | 2014 May 5 | 24692213 |
| Characterization of a tryptophan 6-halogenase from Streptomyces toxytricini. | Zeng J, Zhan J | 2011 Aug | 21424165 |
| RHEA:55900 | chloride + FADH2 + L-tryptophan + O2 = 6-chloro-L-tryptophan + FAD + 2 H2O |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]:[cH;+0:12]:[*:13].[Cl-;H0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]:[c;H0;+0:12](:[*:13])-[Cl;H0;+0:14].[OH2;+0:15].[OH2;+0:16] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase. | Shepherd SA, Menon BR, Fisk H, Struck AW, Levy C, Leys D, Micklefield J | 2016 May 3 | 26840773 |
| A tryptophan 6-halogenase and an amidotransferase are involved in thienodolin biosynthesis. | Milbredt D, Patallo EP, van Pée KH | 2014 May 5 | 24692213 |
| Characterization of a tryptophan 6-halogenase from Streptomyces toxytricini. | Zeng J, Zhan J | 2011 Aug | 21424165 |