EC number:1.14.19.60

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
ID:1.14.19.60
Description:7-chloro-L-tryptophan 6-halogenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.19.60
BRENDA Enzyme Link: BRENDA 1.14.19.60
KEGG Enzyme Link: KEGG1.14.19.60
BioCyc Enzyme Link: BioCyc 1.14.19.60
ExPASy Enzyme Link: ExPASy1.14.19.60
EC2PDB Enzyme Link: EC2PDB 1.14.19.60
ExplorEnz Enzyme Link: ExplorEnz 1.14.19.60
PRIAM enzyme-specific profiles Link: PRIAM 1.14.19.60
IntEnz Enzyme Link: IntEnz 1.14.19.60
MEDLINE Enzyme Link: MEDLINE 1.14.19.60

EC number:1.14.19.60

MSA:

1.14.19.60;
Phylogenetic Tree:

1.14.19.60;
Uniprot:
M-CSA:
RHEA:55904 7-chloro-L-tryptophan + chloride + FADH2 + O2 = 6,7-dichloro-L-tryptophan + FAD + 2 H2O
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]:[cH;+0:12]:[*:13].[Cl-;H0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]:[c;H0;+0:12](:[*:13])-[Cl;H0;+0:14].[OH2;+0:15].[OH2;+0:16]
Reaction
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References

TitleAuthorsDatePubMed ID
Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly.Heemstra JR Jr, Walsh CT2008 Oct 2918828589