EC number:1.14.19.62
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| ID: | 1.14.19.62 | ||
|---|---|---|---|
| Description: | Secologanin synthase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.19.62 |
| BRENDA Enzyme Link: | BRENDA 1.14.19.62 |
| KEGG Enzyme Link: | KEGG1.14.19.62 |
| BioCyc Enzyme Link: | BioCyc 1.14.19.62 |
| ExPASy Enzyme Link: | ExPASy1.14.19.62 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.19.62 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.19.62 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.19.62 |
| IntEnz Enzyme Link: | IntEnz 1.14.19.62 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.19.62 |
EC number:1.14.19.62
| MSA: | |
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| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:20585 | loganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[CH3;+0:3])-[CH;+0:4](-[*:5])-[OH;+0:6].[*:7]-[N;H0;+0:8]1-[CH;+0:9]=[C;H0;+0:10](-[*:11])-[CH2;+0:12]-[CH;+0:13]=[CH;+0:14]-1.[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17]>>([*:1]-[CH;+0:2]=[CH2;+0:3].[*:5]-[CH;+0:4]=[O;H0;+0:6]).[*:7]-[n+;H0:8]1:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:1.[OH2;+0:16].[OH2;+0:17] |
| Reaction |  |
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References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. | Irmler S, Schröder G, St-Pierre B, Crouch NP, Hotze M, Schmidt J, Strack D, Matern U, Schröder J | 2000 Dec | 11135113 |
| Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450. | Yamamoto H, Katano N, Ooi A, Inoue K | 2000 Jan | 10656401 |