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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

ID:

1.14.19.67

Description:

Salutaridine synthase.

Alternative Name:

(R)-reticuline oxidase (C-C phenol-coupling).

Prosite:

PDOC00081;

PDB:

PDB	Scop

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UniProtKB Enzyme Link:	UniProtKB 1.14.19.67
BRENDA Enzyme Link:	BRENDA 1.14.19.67
KEGG Enzyme Link:	KEGG1.14.19.67
BioCyc Enzyme Link:	BioCyc 1.14.19.67
ExPASy Enzyme Link:	ExPASy1.14.19.67
EC2PDB Enzyme Link:	EC2PDB 1.14.19.67
ExplorEnz Enzyme Link:	ExplorEnz 1.14.19.67
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.19.67
IntEnz Enzyme Link:	IntEnz 1.14.19.67
MEDLINE Enzyme Link:	MEDLINE 1.14.19.67

RHEA:17713	(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine
RULE(radius=1)	[:1]-[N;H0;+0:2]1-[:3]:[:4]-[NH;+0:5]-[c;H0;+0:6](:[:7]):[c;H0;+0:8]-1:[nH;+0:9]:[:10].([:11]-[c;H0;+0:12]1:[cH;+0:13]:[c;H0;+0:14](-[OH;+0:15]):[c;H0;+0:16](-[:17]):[cH;+0:18]:[c;H0;+0:19]:1-[:20].[:21]:[cH;+0:22]:[:23]).[O;H0;+0:24]=[O;H0;+0:25]>>[:1]-[n;H0;+0:2]1:[:3]:[:4]:[n;H0;+0:5]:[c;H0;+0:6](:[:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[:10].[:21]:[c;H0;+0:22](:[:23])-[C;H0;+0:19]1(-[:20])-[CH;+0:18]=[C;H0;+0:16](-[:17])-[C;H0;+0:14](=[O;H0;+0:15])-[CH;+0:13]=[C;H0;+0:12]-1-[:11].[OH2;+0:24].[OH2;+0:25]
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Title	Authors	Date	PubMed ID
CYP719B1 is salutaridine synthase, the C-C phenol-coupling enzyme of morphine biosynthesis in opium poppy.	Gesell A, Rolf M, Ziegler J, Díaz Chávez ML, Huang FC, Kutchan TM	2009 Sep 4	19567876