EC number:1.14.19.68

Enzyme

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EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
ID:1.14.19.68
Description:(S)-canadine synthase.
Alternative Name: CYP719A.
(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming).
(S)-tetrahydroberberine synthase.
Prosite: PDOC00081;
PDB:
PDBScop

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.19.68
BRENDA Enzyme Link: BRENDA 1.14.19.68
KEGG Enzyme Link: KEGG1.14.19.68
BioCyc Enzyme Link: BioCyc 1.14.19.68
ExPASy Enzyme Link: ExPASy1.14.19.68
EC2PDB Enzyme Link: EC2PDB 1.14.19.68
ExplorEnz Enzyme Link: ExplorEnz 1.14.19.68
PRIAM enzyme-specific profiles Link: PRIAM 1.14.19.68
IntEnz Enzyme Link: IntEnz 1.14.19.68
MEDLINE Enzyme Link: MEDLINE 1.14.19.68

EC number:1.14.19.68

MSA:

1.14.19.68;
Phylogenetic Tree:

1.14.19.68;
Uniprot:
M-CSA:
RHEA:21456 (S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]
RULE(radius=1) ([*:1]-[CH3;+0:2].[*:3]-[OH;+0:4]).[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[H+;H0:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:3]-[O;H0;+0:4]-[CH2;+0:2]-[*:1].[*:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1.[OH2;+0:14].[OH2;+0:15]
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References

TitleAuthorsDatePubMed ID
Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells.Ikezawa N, Tanaka M, Nagayoshi M, Shinkyo R, Sakaki T, Inouye K, Sato F2003 Oct 312732624