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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

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UniProtKB Enzyme Link:	UniProtKB 1.14.19.9
BRENDA Enzyme Link:	BRENDA 1.14.19.9
KEGG Enzyme Link:	KEGG1.14.19.9
BioCyc Enzyme Link:	BioCyc 1.14.19.9
ExPASy Enzyme Link:	ExPASy1.14.19.9
EC2PDB Enzyme Link:	EC2PDB 1.14.19.9
ExplorEnz Enzyme Link:	ExplorEnz 1.14.19.9
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.19.9
IntEnz Enzyme Link:	IntEnz 1.14.19.9
MEDLINE Enzyme Link:	MEDLINE 1.14.19.9

RHEA:26494	chloride + FADH2 + L-tryptophan + O2 = 7-chloro-L-tryptophan + FAD + 2 H2O
RULE(radius=1)	[:1]-[N;H0;+0:2]1-[:3]:[:4]-[NH;+0:5]-[c;H0;+0:6](:[:7]):[c;H0;+0:8]-1:[nH;+0:9]:[:10].[:11]:[cH;+0:12]:[:13].[Cl-;H0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[:1]-[n;H0;+0:2]1:[:3]:[:4]:[n;H0;+0:5]:[c;H0;+0:6](:[:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[:10].[:11]:[c;H0;+0:12](:[:13])-[Cl;H0;+0:14].[OH2;+0:15].[OH2;+0:16]
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Title	Authors	Date	PubMed ID
The structure of flavin-dependent tryptophan 7-halogenase RebH.	Bitto E, Huang Y, Bingman CA, Singh S, Thorson JS, Phillips GN Jr	2008 Jan 1	17876823
Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis.	Yeh E, Garneau S, Walsh CT	2005 Mar 15	15743914
Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens.	Dong C, Kotzsch A, Dorward M, van Pée KH, Naismith JH	2004 Aug	15272170