EC number:1.14.20.8

Enzyme

Download
EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated
ID:1.14.20.8
Description:(-)-deoxypodophyllotoxin synthase.

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.20.8
BRENDA Enzyme Link: BRENDA 1.14.20.8
KEGG Enzyme Link: KEGG1.14.20.8
BioCyc Enzyme Link: BioCyc 1.14.20.8
ExPASy Enzyme Link: ExPASy1.14.20.8
EC2PDB Enzyme Link: EC2PDB 1.14.20.8
ExplorEnz Enzyme Link: ExplorEnz 1.14.20.8
PRIAM enzyme-specific profiles Link: PRIAM 1.14.20.8
IntEnz Enzyme Link: IntEnz 1.14.20.8
MEDLINE Enzyme Link: MEDLINE 1.14.20.8

EC number:1.14.20.8

MSA:

1.14.20.8;
Phylogenetic Tree:

1.14.20.8;
Uniprot:
M-CSA:
RHEA:48744 (-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + CO2 + H2O + succinate
RULE(radius=1) ([*:1]-[CH2;+0:2]-[*:3].[*:4]:[cH;+0:5]:[*:6]).[*:7]=[C;H0;+0:8](-[OH;+0:9])-[C;H0;+0:10](=[*:11])-[*:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH;+0:2](-[*:3])-[c;H0;+0:5](:[*:4]):[*:6].[*:11]=[C;H0;+0:10](-[*:12])-[OH;+0:13].[*:7]=[C;H0;+0:8]=[O;H0;+0:9].[OH2;+0:14]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.Lau W, Sattely ES2015 Sep 1126359402