EC number:1.14.99.46
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.99 Miscellaneous |
| ID: | 1.14.99.46 |
|---|---|
| Description: | Pyrimidine monooxygenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.99.46 |
| BRENDA Enzyme Link: | BRENDA 1.14.99.46 |
| KEGG Enzyme Link: | KEGG1.14.99.46 |
| BioCyc Enzyme Link: | BioCyc 1.14.99.46 |
| ExPASy Enzyme Link: | ExPASy1.14.99.46 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.99.46 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.99.46 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.99.46 |
| IntEnz Enzyme Link: | IntEnz 1.14.99.46 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.99.46 |
EC number:1.14.99.46
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:31599 | FMNH2 + O2 + thymine = (Z)-2-methyl-ureidoacrylate peracid + FMN + H(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]=[c;H0;+0:12]1:[nH;+0:13]:[cH;+0:14]:[c;H0;+0:15](-[*:16]):[c;H0;+0:17](=[*:18]):[nH;+0:19]:1.[O;H0;+0:20]=[O;H0;+0:21]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]=[C;H0;+0:12](-[NH2;+0:19])-[NH;+0:13]-[CH;+0:14]=[C;H0;+0:15](-[*:16])-[C;H0;+0:17](=[*:18])-[O;H0;+0:20]-[OH;+0:21] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. | Kim KS, Pelton JG, Inwood WB, Andersen U, Kustu S, Wemmer DE | 2010 Aug | 20400551 |
| RHEA:31587 | FMNH2 + O2 + uracil = (Z)-3-ureidoacrylate peracid + FMN + H(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]:[*:4]-[NH;+0:5]-[c;H0;+0:6](:[*:7]):[c;H0;+0:8]-1:[nH;+0:9]:[*:10].[*:11]=[c;H0;+0:12]1:[cH;+0:13]:[cH;+0:14]:[nH;+0:15]:[c;H0;+0:16](=[*:17]):[nH;+0:18]:1.[O;H0;+0:19]=[O;H0;+0:20]>>[*:1]-[n;H0;+0:2]1:[*:3]:[*:4]:[n;H0;+0:5]:[c;H0;+0:6](:[*:7])-[c;H0;+0:8]:1:[n;H0;+0:9]:[*:10].[*:11]=[C;H0;+0:12](-[CH;+0:13]=[CH;+0:14]-[NH;+0:15]-[C;H0;+0:16](=[*:17])-[NH2;+0:18])-[O;H0;+0:19]-[OH;+0:20] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. | Kim KS, Pelton JG, Inwood WB, Andersen U, Kustu S, Wemmer DE | 2010 Aug | 20400551 |
| Catalysis of a flavoenzyme-mediated amide hydrolysis. | Mukherjee T, Zhang Y, Abdelwahed S, Ealick SE, Begley TP | 2010 Apr 28 | 20369853 |