EC number:1.17.1.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.17 Acting on CH or CH2 groups |
| 1.17.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.17.1.4 | ||
|---|---|---|---|
| Description: | Xanthine dehydrogenase. | ||
| Alternative Name: |
Xanthine/NAD(+) oxidoreductase. Xanthine-NAD oxidoreductase. Xanthine oxidoreductase. NAD-xanthine dehydrogenase. | ||
| Prosite: | PDOC00484; | ||
| PDB: |
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| Cath: | 1.10.150.120; 3.30.365.10; 3.30.390.50; 3.30.43.10; 3.30.43.30; 3.30.465.10; 3.90.1170.50; 3.10.20.30; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.17.1.4 |
| BRENDA Enzyme Link: | BRENDA 1.17.1.4 |
| KEGG Enzyme Link: | KEGG1.17.1.4 |
| BioCyc Enzyme Link: | BioCyc 1.17.1.4 |
| ExPASy Enzyme Link: | ExPASy1.17.1.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.17.1.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.17.1.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.17.1.4 |
| IntEnz Enzyme Link: | IntEnz 1.17.1.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.17.1.4 |
| RHEA:24670 | H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[cH;+0:10]:[n;H0;+0:11]:[*:12]1:[*:13]:[nH;+0:14]:[*:15]:[n;H0;+0:16]:1.[OH2;+0:17]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[c;H0;+0:10](=[O;H0;+0:17]):[nH;+0:11]:[*:12]1:[*:13]:[n;H0;+0:14]:[*:15]:[nH;+0:16]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus. | Truglio JJ, Theis K, Leimkühler S, Rappa R, Rajagopalan KV, Kisker C | 2002 Jan | 11796116 |
| Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage. | Xi H, Schneider BL, Reitzer L | 2000 Oct | 10986234 |
| RHEA:16669 | H2O + NAD(+) + xanthine = H(+) + NADH + urate |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[n;H0;+0:10]:[cH;+0:11]:[*:12].[OH2;+0:13]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[nH;+0:10]:[c;H0;+0:11](:[*:12])=[O;H0;+0:13] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase): structural analysis of the protein and chromosomal location of the gene. | Ichida K, Amaya Y, Noda K, Minoshima S, Hosoya T, Sakai O, Shimizu N, Nishino T | 1993 Nov 15 | 8224915 |
| Purification and properties of a new glutathione-dependent thiol:disulphide oxidoreductase from rat liver. | Battelli MG, Lorenzoni E | 1982 Oct 1 | 6960894 |
| Purification and properties of xanthine dehydroganase from Micrococcus lactilyticus. | Smith ST, Rajagopalan KV, Handler P | 1967 Sep 25 | 6061702 |
| The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme. | Corte ED, Stirpe F | 1972 Feb | 4342395 |
| Purification and properties of chicken liver xanthine dehydrogenase. | Rajagopalan KV, Handler P | 1967 Sep 25 | 4294045 |
| The presence of desulfo xanthine dehydrogenase in purified and crude enzyme preparations from rat liver. | Ikegami T, Nishino T | 1986 Jun | 3459393 |
| Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues. | Engerson TD, McKelvey TG, Rhyne DB, Boggio EB, Snyder SJ, Jones HP | 1987 Jun | 3294898 |
| Interconversion between NAD-dependent and O2-dependent types of rat liver xanthine dehydrogenase and difference in kinetic and redox properties between them. | Saito T, Nishino T, Tsushima K | 1989 | 2610112 |
| Xanthine dehydrogenase processes retinol to retinoic acid in human mammary epithelial cells. | Taibi G, Di Gaudio F, Nicotra CM | 2008 Jun | 18569334 |
| Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase. | Nishino T, Okamoto K, Eger BT, Pai EF, Nishino T | 2008 Jul | 18513323 |
| PURIFICATION OF XANTHINE DEHYDROGENASE FROM DROSOPHILA MELANOGASTER. | PARZEN SD, FOX AS | 1964 Dec 23 | 14264879 |
| The Mononuclear Molybdenum Enzymes. | Hille R | 1996 Nov 7 | 11848841 |
| Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus. | Truglio JJ, Theis K, Leimkühler S, Rappa R, Rajagopalan KV, Kisker C | 2002 Jan | 11796116 |
| Xanthine dehydrogenase from Pseudomonas putida 86: specificity, oxidation-reduction potentials of its redox-active centers, and first EPR characterization. | Parschat K, Canne C, Hüttermann J, Kappl R, Fetzner S | 2001 Jan 12 | 11341925 |
| Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion. | Enroth C, Eger BT, Okamoto K, Nishino T, Nishino T, Pai EF | 2000 Sep 26 | 11005854 |