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1. Oxidoreductases

1.17 Acting on CH or CH2 groups

1.17.3 With oxygen as acceptor

ID:

1.17.3.2

Description:

Xanthine oxidase.

Alternative Name:

Xanthine oxidoreductase.
Schardinger enzyme.
Hypoxanthine-xanthine oxidase.
Hypoxanthine oxidase.

Prosite:

PDOC00484;

PDB:

PDB	Scop

Cath:

1.10.150.120; 3.30.365.10; 3.30.390.50; 3.30.43.10; 3.30.43.30; 3.30.465.10; 3.90.1170.50; 3.10.20.30;

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UniProtKB Enzyme Link:	UniProtKB 1.17.3.2
BRENDA Enzyme Link:	BRENDA 1.17.3.2
KEGG Enzyme Link:	KEGG1.17.3.2
BioCyc Enzyme Link:	BioCyc 1.17.3.2
ExPASy Enzyme Link:	ExPASy1.17.3.2
EC2PDB Enzyme Link:	EC2PDB 1.17.3.2
ExplorEnz Enzyme Link:	ExplorEnz 1.17.3.2
PRIAM enzyme-specific profiles Link:	PRIAM 1.17.3.2
IntEnz Enzyme Link:	IntEnz 1.17.3.2
MEDLINE Enzyme Link:	MEDLINE 1.17.3.2

Title	Authors	Date	PubMed ID
Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase.	Nishino T, Okamoto K, Eger BT, Pai EF, Nishino T	2008 Jul	18513323
Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate.	Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T	2010 Dec 8	21077683
Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid.	Cao H, Pauff JM, Hille R	2010 Sep 3	20615869
QM/MM studies of xanthine oxidase: variations of cofactor, substrate, and active-site Glu802.	Metz S, Thiel W	2010 Jan 28	20050623
Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin.	Pauff JM, Hille R	2009 Apr	19388706
Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate.	Yamaguchi Y, Matsumura T, Ichida K, Okamoto K, Nishino T	2007 Apr	17301077
Purification, crystallization and preliminary X-ray diffraction studies of xanthine dehydrogenase and xanthine oxidase isolated from bovine milk.	Eger BT, Okamoto K, Enroth C, Sato M, Nishino T, Pai EF, Nishino T	2000 Dec	11092937