EC number:1.17.7.3
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.17 Acting on CH or CH2 groups |
| 1.17.7 With an iron-sulfur protein as acceptor |
| ID: | 1.17.7.3 |
|---|---|
| Description: | (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin). |
| Alternative Name: |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase. (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase. |
| Cath: | 3.20.20.20; 3.30.413.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.17.7.3 |
| BRENDA Enzyme Link: | BRENDA 1.17.7.3 |
| KEGG Enzyme Link: | KEGG1.17.7.3 |
| BioCyc Enzyme Link: | BioCyc 1.17.7.3 |
| ExPASy Enzyme Link: | ExPASy1.17.7.3 |
| EC2PDB Enzyme Link: | EC2PDB 1.17.7.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.17.7.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.17.7.3 |
| IntEnz Enzyme Link: | IntEnz 1.17.7.3 |
| MEDLINE Enzyme Link: | MEDLINE 1.17.7.3 |
| RHEA:43604 | (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin] |
| RULE(radius=1) | ([*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[OH;+0:7]).[*:8]-[n;H0;+0:9]1:[*:10]:[*:11]:[n;H0;+0:12]:[c;H0;+0:13](:[*:14])-[c;H0;+0:15]:1:[n;H0;+0:16]:[*:17].[H+;H0:18].[H+;H0:19].[OH2;+0:20]>>[*:8]-[N;H0;+0:9]1-[*:10]:[*:11]-[NH;+0:12]-[c;H0;+0:13](:[*:14]):[c;H0;+0:15]-1:[nH;+0:16]:[*:17].[*:6]-[O;H0;+0:7]-[C;H0;+0:3](-[*:4])(-[*:5])-[CH;+0:2](-[*:1])-[OH;+0:20] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli. | Zepeck F, Gräwert T, Kaiser J, Schramek N, Eisenreich W, Bacher A, Rohdich F | 2005 Nov 11 | 16268586 |
| fldA is an essential gene required in the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis. | Puan KJ, Wang H, Dairi T, Kuzuyama T, Morita CT | 2005 Jul 4 | 15978585 |
| Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. | Kollas AK, Duin EC, Eberl M, Altincicek B, Hintz M, Reichenberg A, Henschker D, Henne A, Steinbrecher I, Ostrovsky DN, Hedderich R, Beck E, Jomaa H, Wiesner J | 2002 Dec 18 | 12482607 |
| Isoprenoid biosynthesis through the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) is a [4Fe-4S] protein. | Seemann M, Bui BT, Wolff M, Tritsch D, Campos N, Boronat A, Marquet A, Rohmer M | 2002 Nov 15 | 12434382 |
| Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein. | Hecht S, Eisenreich W, Adam P, Amslinger S, Kis K, Bacher A, Arigoni D, Rohdich F | 2001 Dec 18 | 11752431 |
| The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein. | Rohdich F, Zepeck F, Adam P, Hecht S, Kaiser J, Laupitz R, Gräwert T, Amslinger S, Eisenreich W, Bacher A, Arigoni D | 2003 Feb 18 | 12571359 |