EC number:1.17.7.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.17 Acting on CH or CH2 groups |
| 1.17.7 With an iron-sulfur protein as acceptor |
| ID: | 1.17.7.4 |
|---|---|
| Description: | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase. |
| Alternative Name: |
HMBPP reductase. (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase. |
| Cath: | 3.40.1010.20; 3.40.50.11270; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.17.7.4 |
| BRENDA Enzyme Link: | BRENDA 1.17.7.4 |
| KEGG Enzyme Link: | KEGG1.17.7.4 |
| BioCyc Enzyme Link: | BioCyc 1.17.7.4 |
| ExPASy Enzyme Link: | ExPASy1.17.7.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.17.7.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.17.7.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.17.7.4 |
| IntEnz Enzyme Link: | IntEnz 1.17.7.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.17.7.4 |
| RHEA:24825 | dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]-[Fe+;H0:4]-[*:5].[*:6]-[Fe+;H0:7]-[*:8].[OH2;+0:9]>>[*:1]-[CH2;+0:2]-[OH;+0:9].[*:3]-[Fe;H0;+0:4]-[*:5].[*:6]-[Fe;H0;+0:7]-[*:8] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum. | Röhrich RC, Englert N, Troschke K, Reichenberg A, Hintz M, Seeber F, Balconi E, Aliverti A, Zanetti G, Köhler U, Pfeiffer M, Beck E, Jomaa H, Wiesner J | 2005 Nov 21 | 16289098 |
| IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis. | Gräwert T, Kaiser J, Zepeck F, Laupitz R, Hecht S, Amslinger S, Schramek N, Schleicher E, Weber S, Haslbeck M, Buchner J, Rieder C, Arigoni D, Bacher A, Eisenreich W, Rohdich F | 2004 Oct 13 | 15469281 |
| Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein. | Wolff M, Seemann M, Tse Sum Bui B, Frapart Y, Tritsch D, Garcia Estrabot A, Rodríguez-Concepción M, Boronat A, Marquet A, Rohmer M | 2003 Apr 24 | 12706830 |
| The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein. | Rohdich F, Zepeck F, Adam P, Hecht S, Kaiser J, Laupitz R, Gräwert T, Amslinger S, Eisenreich W, Bacher A, Arigoni D | 2003 Feb 18 | 12571359 |
| LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. | Altincicek B, Duin EC, Reichenberg A, Hedderich R, Kollas AK, Hintz M, Wagner S, Wiesner J, Beck E, Jomaa H | 2002 Dec 18 | 12482608 |
| Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase. | Adam P, Hecht S, Eisenreich W, Kaiser J, Grawert T, Arigoni D, Bacher A, Rohdich F | 2002 Sep 17 | 12198182 |
| Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. | Rohdich F, Hecht S, Gärtner K, Adam P, Krieger C, Amslinger S, Arigoni D, Bacher A, Eisenreich W | 2002 Feb 5 | 11818558 |
| Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. | Hintz M, Reichenberg A, Altincicek B, Bahr U, Gschwind RM, Kollas AK, Beck E, Wiesner J, Eberl M, Jomaa H | 2001 Dec 7 | 11741609 |
| RHEA:24488 | H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[C;H0;+0:3](-[*:4])=[CH2;+0:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1.[OH2;+0:14]>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[CH2;+0:5]-[OH;+0:14].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum. | Röhrich RC, Englert N, Troschke K, Reichenberg A, Hintz M, Seeber F, Balconi E, Aliverti A, Zanetti G, Köhler U, Pfeiffer M, Beck E, Jomaa H, Wiesner J | 2005 Nov 21 | 16289098 |
| IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis. | Gräwert T, Kaiser J, Zepeck F, Laupitz R, Hecht S, Amslinger S, Schramek N, Schleicher E, Weber S, Haslbeck M, Buchner J, Rieder C, Arigoni D, Bacher A, Eisenreich W, Rohdich F | 2004 Oct 13 | 15469281 |
| Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein. | Wolff M, Seemann M, Tse Sum Bui B, Frapart Y, Tritsch D, Garcia Estrabot A, Rodríguez-Concepción M, Boronat A, Marquet A, Rohmer M | 2003 Apr 24 | 12706830 |
| The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein. | Rohdich F, Zepeck F, Adam P, Hecht S, Kaiser J, Laupitz R, Gräwert T, Amslinger S, Eisenreich W, Bacher A, Arigoni D | 2003 Feb 18 | 12571359 |
| LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. | Altincicek B, Duin EC, Reichenberg A, Hedderich R, Kollas AK, Hintz M, Wagner S, Wiesner J, Beck E, Jomaa H | 2002 Dec 18 | 12482608 |
| Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase. | Adam P, Hecht S, Eisenreich W, Kaiser J, Grawert T, Arigoni D, Bacher A, Rohdich F | 2002 Sep 17 | 12198182 |
| Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. | Rohdich F, Hecht S, Gärtner K, Adam P, Krieger C, Amslinger S, Arigoni D, Bacher A, Eisenreich W | 2002 Feb 5 | 11818558 |
| Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. | Hintz M, Reichenberg A, Altincicek B, Bahr U, Gschwind RM, Kollas AK, Beck E, Wiesner J, Eberl M, Jomaa H | 2001 Dec 7 | 11741609 |