EC number:1.18.1.6
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.18 Acting on iron-sulfur proteins as donors |
| 1.18.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.18.1.6 |
|---|---|
| Description: | Adrenodoxin-NADP(+) reductase. |
| Alternative Name: |
Nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase. Adrenodoxin reductase. |
| Cath: | 1.10.630.10; 3.40.50.720; 3.50.50.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.18.1.6 |
| BRENDA Enzyme Link: | BRENDA 1.18.1.6 |
| KEGG Enzyme Link: | KEGG1.18.1.6 |
| BioCyc Enzyme Link: | BioCyc 1.18.1.6 |
| ExPASy Enzyme Link: | ExPASy1.18.1.6 |
| EC2PDB Enzyme Link: | EC2PDB 1.18.1.6 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.18.1.6 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.18.1.6 |
| IntEnz Enzyme Link: | IntEnz 1.18.1.6 |
| MEDLINE Enzyme Link: | MEDLINE 1.18.1.6 |
| RHEA:42312 | H(+) + NADP(+) + 2 reduced [adrenodoxin] = NADPH + 2 oxidized [adrenodoxin] |
| RULE(radius=1) | [*:1]-[Fe;H0;+0:2]-[*:3].[*:4]-[Fe;H0;+0:5]-[*:6].[*:7]-[n+;H0:8]1:[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:1.[H+;H0:15]>>[*:1]-[Fe+;H0:2]-[*:3].[*:4]-[Fe+;H0:5]-[*:6].[*:7]-[N;H0;+0:8]1-[CH;+0:9]=[CH;+0:10]-[CH2;+0:11]-[C;H0;+0:12](-[*:13])=[CH;+0:14]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and functional characterization of bovine adrenodoxin reductase by limited proteolysis. | Warburton RJ, Seybert DW | 1995 Jan 5 | 7811729 |
| Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin. | Hanukoglu I, Jefcoate CR | 1980 Apr 10 | 6766943 |
| Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein). | Chu JW, Kimura T | 1973 Mar 25 | 4144106 |
| cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases. | Hanukoglu I, Gutfinger T | 1989 Mar 15 | 2924777 |
| Purification and crystallization of NADPH-adrenodoxin reductase from bovine adrenocortical mitochondria. | Sugiyama T, Yamano T | 1975 Mar 15 | 235468 |
| Identification and molecular characterization of mitochondrial ferredoxins and ferredoxin reductase from Arabidopsis. | Takubo K, Morikawa T, Nonaka Y, Mizutani M, Takenaka S, Takabe K, Takahashi MA, Ohta D | 2003 Jul | 13677469 |
| The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis. | Ziegler GA, Vonrhein C, Hanukoglu I, Schulz GE | 1999 Jun 18 | 10369776 |
| Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation. | Hanukoglu I, Hanukoglu Z | 1986 May 15 | 3011431 |