EC Tree |
1. Oxidoreductases |
1.2 Acting on the aldehyde or oxo group of donors |
1.2.1 With NAD+ or NADP+ as acceptor |
ID: | 1.2.1.100 |
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Description: | 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase. |
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.UniProtKB Enzyme Link: | UniProtKB 1.2.1.100 |
BRENDA Enzyme Link: | BRENDA 1.2.1.100 |
KEGG Enzyme Link: | KEGG1.2.1.100 |
BioCyc Enzyme Link: | BioCyc 1.2.1.100 |
ExPASy Enzyme Link: | ExPASy1.2.1.100 |
EC2PDB Enzyme Link: | EC2PDB 1.2.1.100 |
ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.100 |
PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.100 |
IntEnz Enzyme Link: | IntEnz 1.2.1.100 |
MEDLINE Enzyme Link: | MEDLINE 1.2.1.100 |
MSA: | |
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Phylogenetic Tree: | |
Uniprot: | |
M-CSA: |
RHEA:19693 | 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH |
RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
Reaction | ![]() |
Core-to-Core |
Title | Authors | Date | PubMed ID |
---|---|---|---|
Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. | Lee YC, Nelson MJ, Snell EE | 1986 Nov 15 | 3533936 |
Crystal structure of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD⁺-dependent dismutase from Mesorhizobium loti. | Mugo AN, Kobayashi J, Mikami B, Yoshikane Y, Yagi T, Ohnishi K | 2015 Jan 2 | 25446130 |
Gene identification and characterization of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD+-dependent dismutase. | Yokochi N, Yoshikane Y, Matsumoto S, Fujisawa M, Ohnishi K, Yagi T | 2009 Apr | 19218190 |