Enzyme

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     1. Oxidoreductases
        1.2 Acting on the aldehyde or oxo group of donors
            1.2.1 With NAD+ or NADP+ as acceptor
ID:1.2.1.100
Description:5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.2.1.100
BRENDA Enzyme Link: BRENDA 1.2.1.100
KEGG Enzyme Link: KEGG1.2.1.100
BioCyc Enzyme Link: BioCyc 1.2.1.100
ExPASy Enzyme Link: ExPASy1.2.1.100
EC2PDB Enzyme Link: EC2PDB 1.2.1.100
ExplorEnz Enzyme Link: ExplorEnz 1.2.1.100
PRIAM enzyme-specific profiles Link: PRIAM 1.2.1.100
IntEnz Enzyme Link: IntEnz 1.2.1.100
MEDLINE Enzyme Link: MEDLINE 1.2.1.100
MSA:

1.2.1.100;

Phylogenetic Tree:

1.2.1.100;

Uniprot:
M-CSA:
RHEA:19693 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH
RULE(radius=1) [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]
Reaction
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References

TitleAuthorsDatePubMed ID
Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase.Lee YC, Nelson MJ, Snell EE1986 Nov 153533936
Crystal structure of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD⁺-dependent dismutase from Mesorhizobium loti.Mugo AN, Kobayashi J, Mikami B, Yoshikane Y, Yagi T, Ohnishi K2015 Jan 225446130
Gene identification and characterization of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD+-dependent dismutase.Yokochi N, Yoshikane Y, Matsumoto S, Fujisawa M, Ohnishi K, Yagi T2009 Apr19218190