EC number:1.2.1.11
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.11 |
|---|---|
| Description: | Aspartate-semialdehyde dehydrogenase. |
| Alternative Name: |
L-aspartate-beta-semialdehyde dehydrogenase. Aspartic semialdehyde dehydrogenase. ASA dehydrogenase. |
| Prosite: | PDOC00847; |
| PDB: |
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| Cath: | 3.30.360.10; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.11 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.11 |
| KEGG Enzyme Link: | KEGG1.2.1.11 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.11 |
| ExPASy Enzyme Link: | ExPASy1.2.1.11 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.11 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.11 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.11 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.11 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.11 |
| RHEA:24284 | L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[n+;H0:4]1:[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:1.[*:11]=[CH;+0:12]-[*:13]>>[*:3]-[N;H0;+0:4]1-[CH;+0:5]=[CH;+0:6]-[CH2;+0:7]-[C;H0;+0:8](-[*:9])=[CH;+0:10]-1.[*:11]=[C;H0;+0:12](-[*:13])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Aspartate-beta-semialdehyde dehydrogenase from Escherichia coli. Purification and general properties. | Biellmann JF, Eid P, Hirth C, Jörnvall H | 1980 Feb | 6102909 |
| Purification, crystallization and preliminary X-ray diffraction analysis of aspartate semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis. | Vyas R, Kumar V, Panjikar S, Karthikeyan S, Kishan KV, Tewari R, Weiss MS | 2008 Mar 1 | 18323599 |
| Cloning and characterization of aspartate-beta-semialdehyde dehydrogenase from Mycobacterium tuberculosis H37 Rv. | Shafiani S, Sharma P, Vohra RM, Tewari R | 2005 | 15752328 |
| The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase. | Blanco J, Moore RA, Faehnle CR, Coe DM, Viola RE | 2004 Aug | 15272161 |
| Expression and purification of aspartate beta-semialdehyde dehydrogenase from infectious microorganisms. | Moore RA, Bocik WE, Viola RE | 2002 Jun | 12071715 |
| An integrated study of threonine-pathway enzyme kinetics in Escherichia coli. | Chassagnole C, Raïs B, Quentin E, Fell DA, Mazat JP | 2001 Jun 1 | 11368768 |