EC number:1.2.1.18
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.18 |
|---|---|
| Description: | Malonate-semialdehyde dehydrogenase (acetylating). |
| Cath: | 3.40.605.10; 3.40.309.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.18 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.18 |
| KEGG Enzyme Link: | KEGG1.2.1.18 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.18 |
| ExPASy Enzyme Link: | ExPASy1.2.1.18 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.18 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.18 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.18 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.18 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.18 |
| RHEA:22992 | 3-oxopropanoate + CoA + NAD(+) = acetyl-CoA + CO2 + NADH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[c;H0;+0:4]1:[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[n+;H0:8](-[*:9]):[cH;+0:10]:1.[*:11]=[CH;+0:12]-[CH2;+0:13]-[C;H0;+0:14](=[*:15])-[OH;+0:16]>>[*:3]-[C;H0;+0:4]1=[CH;+0:10]-[N;H0;+0:8](-[*:9])-[CH;+0:7]=[CH;+0:6]-[CH2;+0:5]-1.[*:1]-[S;H0;+0:2]-[C;H0;+0:12](=[*:11])-[CH3;+0:13].[*:15]=[C;H0;+0:14]=[O;H0;+0:16] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanistic characterization of the MSDH (methylmalonate semialdehyde dehydrogenase) from Bacillus subtilis. | Stines-Chaumeil C, Talfournier F, Branlant G | 2006 Apr 1 | 16332250 |
| RHEA:22988 | 3-oxopropanoate + CoA + NADP(+) = acetyl-CoA + CO2 + NADPH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[c;H0;+0:4]1:[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[n+;H0:8](-[*:9]):[cH;+0:10]:1.[*:11]=[C;H0;+0:12](-[OH;+0:13])-[CH2;+0:14]-[CH;+0:15]=[*:16]>>[*:3]-[C;H0;+0:4]1=[CH;+0:10]-[N;H0;+0:8](-[*:9])-[CH;+0:7]=[CH;+0:6]-[CH2;+0:5]-1.[*:1]-[S;H0;+0:2]-[C;H0;+0:15](=[*:16])-[CH3;+0:14].[*:11]=[C;H0;+0:12]=[O;H0;+0:13] |
| Reaction |  |
| Core-to-Core |