EC number:1.2.1.23
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.23 |
|---|---|
| Description: | 2-oxoaldehyde dehydrogenase (NAD(+)). |
| Alternative Name: |
Methylglyoxal dehydrogenase. Alpha-ketoaldehyde dehydrogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.23 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.23 |
| KEGG Enzyme Link: | KEGG1.2.1.23 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.23 |
| ExPASy Enzyme Link: | ExPASy1.2.1.23 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.23 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.23 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.23 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.23 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.23 |
| RHEA:22276 | 2-oxoaldehyde + H2O + NAD(+) = a 2-oxocarboxylate + 2 H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[*:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1.[OH2;+0:12]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:12].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase. | Ray M, Ray S | 1982 Sep 25 | 7107626 |
| Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate. | Ray S, Ray M | 1982 Sep 25 | 7107625 |