EC number:1.2.1.25
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.25 |
|---|---|
| Description: | 2-oxoisovalerate dehydrogenase (acylating). |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.25 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.25 |
| KEGG Enzyme Link: | KEGG1.2.1.25 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.25 |
| ExPASy Enzyme Link: | ExPASy1.2.1.25 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.25 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.25 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.25 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.25 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.25 |
| RHEA:13997 | 3-methyl-2-oxobutanoate + CoA + NAD(+) = 2-methylpropanoyl-CoA + CO2 + NADH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[c;H0;+0:4]1:[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[n+;H0:8](-[*:9]):[cH;+0:10]:1.[*:11]=[C;H0;+0:12](-[OH;+0:13])-[C;H0;+0:14](=[*:15])-[*:16]>>[*:3]-[C;H0;+0:4]1=[CH;+0:10]-[N;H0;+0:8](-[*:9])-[CH;+0:7]=[CH;+0:6]-[CH2;+0:5]-1.[*:1]-[S;H0;+0:2]-[C;H0;+0:14](=[*:15])-[*:16].[*:11]=[C;H0;+0:12]=[O;H0;+0:13] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain alpha-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis. | Namba Y, Yoshizawa K, Ejima A, Hayashi T, Kaneda T | 1969 Aug 25 | 4308861 |
| RHEA:25177 | 4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-methylbutanoyl-CoA + CO2 + NADH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[c;H0;+0:4]1:[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[n+;H0:8](-[*:9]):[cH;+0:10]:1.[*:11]=[C;H0;+0:12](-[OH;+0:13])-[C;H0;+0:14](=[*:15])-[*:16]>>[*:3]-[C;H0;+0:4]1=[CH;+0:10]-[N;H0;+0:8](-[*:9])-[CH;+0:7]=[CH;+0:6]-[CH2;+0:5]-1.[*:1]-[S;H0;+0:2]-[C;H0;+0:14](=[*:15])-[*:16].[*:11]=[C;H0;+0:12]=[O;H0;+0:13] |
| Reaction |  |
| Core-to-Core |
| RHEA:30907 | (S)-3-methyl-2-oxopentanoate + CoA + NAD(+) = 2-methylbutanoyl-CoA + CO2 + NADH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[c;H0;+0:4]1:[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[n+;H0:8](-[*:9]):[cH;+0:10]:1.[*:11]=[C;H0;+0:12](-[OH;+0:13])-[C;H0;+0:14](=[*:15])-[*:16]>>[*:3]-[C;H0;+0:4]1=[CH;+0:10]-[N;H0;+0:8](-[*:9])-[CH;+0:7]=[CH;+0:6]-[CH2;+0:5]-1.[*:1]-[S;H0;+0:2]-[C;H0;+0:14](=[*:15])-[*:16].[*:11]=[C;H0;+0:12]=[O;H0;+0:13] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain alpha-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis. | Namba Y, Yoshizawa K, Ejima A, Hayashi T, Kaneda T | 1969 Aug 25 | 4308861 |