EC number:1.2.1.27

Enzyme

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     1. Oxidoreductases
        1.2 Acting on the aldehyde or oxo group of donors
            1.2.1 With NAD+ or NADP+ as acceptor
ID:1.2.1.27
Description:Methylmalonate-semialdehyde dehydrogenase (CoA acylating).
Alternative Name: MSDH.
MMSA dehydrogenase.
Methylmalonate-semialdehyde dehydrogenase (acylating).
Prosite: PDOC00068;
PDB:
PDBScop
Cath: 3.40.605.10; 3.40.309.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.2.1.27
BRENDA Enzyme Link: BRENDA 1.2.1.27
KEGG Enzyme Link: KEGG1.2.1.27
BioCyc Enzyme Link: BioCyc 1.2.1.27
ExPASy Enzyme Link: ExPASy1.2.1.27
EC2PDB Enzyme Link: EC2PDB 1.2.1.27
ExplorEnz Enzyme Link: ExplorEnz 1.2.1.27
PRIAM enzyme-specific profiles Link: PRIAM 1.2.1.27
IntEnz Enzyme Link: IntEnz 1.2.1.27
MEDLINE Enzyme Link: MEDLINE 1.2.1.27

EC number:1.2.1.27

MSA:

1.2.1.27;
Phylogenetic Tree:

1.2.1.27;
Uniprot:
M-CSA:
RHEA:20804 2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA
RULE(radius=1) [*:1]-[SH;+0:2].[*:3]-[c;H0;+0:4]1:[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[n+;H0:8](-[*:9]):[cH;+0:10]:1.[*:11]=[CH;+0:12]-[CH;+0:13](-[*:14])-[C;H0;+0:15](=[*:16])-[*:17].[OH2;+0:18]>>[*:3]-[C;H0;+0:4]1=[CH;+0:10]-[N;H0;+0:8](-[*:9])-[CH;+0:7]=[CH;+0:6]-[CH2;+0:5]-1.[*:1]-[S;H0;+0:2]-[C;H0;+0:12](=[*:11])-[CH2;+0:13]-[*:14].[*:16]=[C;H0;+0:15](-[*:17])-[OH;+0:18]
Reaction
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References

TitleAuthorsDatePubMed ID
Mechanistic characterization of the MSDH (methylmalonate semialdehyde dehydrogenase) from Bacillus subtilis.Stines-Chaumeil C, Talfournier F, Branlant G2006 Apr 116332250
Expression, purification, crystallization and preliminary X-ray diffraction data of methylmalonate-semialdehyde dehydrogenase from Bacillus subtilis.Dubourg H, Stines-Chaumeil C, Didierjean C, Talfournier F, Rahuel-Clermont S, Branlant G, Aubry A2004 Aug15272169