EC number:1.2.1.3

Enzyme

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EC Tree
     1. Oxidoreductases
        1.2 Acting on the aldehyde or oxo group of donors
            1.2.1 With NAD+ or NADP+ as acceptor
ID:1.2.1.3
Description:Aldehyde dehydrogenase (NAD(+)).
Prosite: PDOC00068;
PDB:
PDBScop
1WND 8031267; 8043645; 8031267; 8043645; 8031267; 8043645; 8031267; 8043645;
1WNB 8031267; 8043645; 8031267; 8043645; 8031267; 8043645; 8031267; 8043645;
1O9J 8021520; 8033900; 8021520; 8033900; 8021520; 8033900; 8021520; 8033900;
2ONM 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787;
5L13 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787; 8021407; 8033787;
 » show all
Cath: 3.40.605.10; 3.40.309.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.2.1.3
BRENDA Enzyme Link: BRENDA 1.2.1.3
KEGG Enzyme Link: KEGG1.2.1.3
BioCyc Enzyme Link: BioCyc 1.2.1.3
ExPASy Enzyme Link: ExPASy1.2.1.3
EC2PDB Enzyme Link: EC2PDB 1.2.1.3
ExplorEnz Enzyme Link: ExplorEnz 1.2.1.3
PRIAM enzyme-specific profiles Link: PRIAM 1.2.1.3
IntEnz Enzyme Link: IntEnz 1.2.1.3
MEDLINE Enzyme Link: MEDLINE 1.2.1.3

EC number:1.2.1.3

MSA:

1.2.1.3;
Phylogenetic Tree:

1.2.1.3;
Uniprot:
M-CSA:
RHEA:25294 acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH
RULE(radius=1) [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]
Reaction
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References

TitleAuthorsDatePubMed ID
A multifunctional fermentative alcohol dehydrogenase from the strict aerobe Alcaligenes eutrophus: purification and properties.Steinbüchel A, Schlegel HG1984 Jun 156378632
Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification.Kitamura T, Takagi S, Naganuma T, Kihara A2015 Jan 125286108
Evidence of a plasmid-encoded oxidative xylose-catabolic pathway in Arthrobacter nicotinovorans pAO1.Mihasan M, Stefan M, Hritcu L, Artenie V, Brandsch R2013 Jan23063486
Characterization of alcohol dehydrogenase genes of derepressible wild-type Alcaligenes eutrophus H16 and constitutive mutants.Jendrossek D, Krüger N, Steinbüchel A1990 Sep2144274
Engineering the nucleotide coenzyme specificity and sulfhydryl redox sensitivity of two stress-responsive aldehyde dehydrogenase isoenzymes of Arabidopsis thaliana.Stiti N, Adewale IO, Petersen J, Bartels D, Kirch HH2011 Mar 1521166653
RHEA:16185 an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2]=[*:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1.[OH2;+0:12]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:12].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1
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References

TitleAuthorsDatePubMed ID
Molecular cloning, characterization, and potential roles of cytosolic and mitochondrial aldehyde dehydrogenases in ethanol metabolism in Saccharomyces cerevisiae.Wang X, Mann CJ, Bai Y, Ni L, Weiner H1998 Feb9473035
Cloning and complete nucleotide sequence of a full-length cDNA encoding a catalytically functional tumor-associated aldehyde dehydrogenase.Jones DE Jr, Brennan MD, Hempel J, Lindahl R1988 Mar2831537
Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification.Kitamura T, Takagi S, Naganuma T, Kihara A2015 Jan 125286108
Evidence of a plasmid-encoded oxidative xylose-catabolic pathway in Arthrobacter nicotinovorans pAO1.Mihasan M, Stefan M, Hritcu L, Artenie V, Brandsch R2013 Jan23063486