EC number:1.2.1.36
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.36 |
|---|---|
| Description: | Retinal dehydrogenase. |
| Cath: | 3.40.605.10; 3.40.309.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.36 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.36 |
| KEGG Enzyme Link: | KEGG1.2.1.36 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.36 |
| ExPASy Enzyme Link: | ExPASy1.2.1.36 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.36 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.36 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.36 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.36 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.36 |
| RHEA:42080 | all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid. | Labrecque J, Dumas F, Lacroix A, Bhat PV | 1995 Jan 15 | 7832787 |
| Preparation and properties of retinal-oxidizing enzyme from rat intestinal mucosa. | Moffa DJ, Lotspeich FJ, Krause RF | 1970 Jan 25 | 4312676 |
| Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD<sup>+</sup> and retinoic acid. | Moretti A, Li J, Donini S, Sobol RW, Rizzi M, Garavaglia S | 2016 Oct 19 | 27759097 |
| RHEA:16177 | H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization and localization of an aldehyde dehydrogenase to amacrine cells of bovine retina. | Saari JC, Champer RJ, Asson-Batres MA, Garwin GG, Huang J, Crabb JW, Milam AH | 1995 Mar-Apr | 7786847 |