EC number:1.2.1.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.4 |
|---|---|
| Description: | Aldehyde dehydrogenase (NADP(+)). |
| Cath: | 3.40.605.10; 3.40.309.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.4 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.4 |
| KEGG Enzyme Link: | KEGG1.2.1.4 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.4 |
| ExPASy Enzyme Link: | ExPASy1.2.1.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.4 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.4 |
| RHEA:25298 | acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
| RHEA:11888 | an aldehyde + H2O + NADP(+) = a carboxylate + 2 H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[*:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1.[OH2;+0:12]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:12].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning, characterization, and potential roles of cytosolic and mitochondrial aldehyde dehydrogenases in ethanol metabolism in Saccharomyces cerevisiae. | Wang X, Mann CJ, Bai Y, Ni L, Weiner H | 1998 Feb | 9473035 |
| Cloning and complete nucleotide sequence of a full-length cDNA encoding a catalytically functional tumor-associated aldehyde dehydrogenase. | Jones DE Jr, Brennan MD, Hempel J, Lindahl R | 1988 Mar | 2831537 |
| Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification. | Kitamura T, Takagi S, Naganuma T, Kihara A | 2015 Jan 1 | 25286108 |
| Evidence of a plasmid-encoded oxidative xylose-catabolic pathway in Arthrobacter nicotinovorans pAO1. | Mihasan M, Stefan M, Hritcu L, Artenie V, Brandsch R | 2013 Jan | 23063486 |
| Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. | Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD | 2011 Dec 16 | 22021038 |
| Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli. | Hsu LC, Chang WC, Shibuya A, Yoshida A | 1992 Feb 15 | 1737758 |