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1. Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD+ or NADP+ as acceptor

ID:	1.2.1.51
Description:	Pyruvate dehydrogenase (NADP(+)).
Alternative Name:	Pyruvate:NADP(+) oxidoreductase.

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UniProtKB Enzyme Link:	UniProtKB 1.2.1.51
BRENDA Enzyme Link:	BRENDA 1.2.1.51
KEGG Enzyme Link:	KEGG1.2.1.51
BioCyc Enzyme Link:	BioCyc 1.2.1.51
ExPASy Enzyme Link:	ExPASy1.2.1.51
EC2PDB Enzyme Link:	EC2PDB 1.2.1.51
ExplorEnz Enzyme Link:	ExplorEnz 1.2.1.51
PRIAM enzyme-specific profiles Link:	PRIAM 1.2.1.51
IntEnz Enzyme Link:	IntEnz 1.2.1.51
MEDLINE Enzyme Link:	MEDLINE 1.2.1.51

RHEA:17425	CoA + NADP(+) + pyruvate = acetyl-CoA + CO2 + NADPH
RULE(radius=1)	[:1]-[SH;+0:2].[:3]-[c;H0;+0:4]1:[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[n+;H0:8](-[:9]):[cH;+0:10]:1.[:11]=[C;H0;+0:12](-[:13])-[C;H0;+0:14](=[:15])-[OH;+0:16]>>[:3]-[C;H0;+0:4]1=[CH;+0:10]-[N;H0;+0:8](-[:9])-[CH;+0:7]=[CH;+0:6]-[CH2;+0:5]-1.[:11]=[C;H0;+0:12](-[:13])-[S;H0;+0:2]-[:1].[:15]=[C;H0;+0:14]=[O;H0;+0:16]
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Title	Authors	Date	PubMed ID
Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis.	Inui H, Miyatake K, Nakano Y, Kitaoka S	1984 Sep	6438078
Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis.	Inui H, Ono K, Miyatake K, Nakano Y, Kitaoka S	1987 Jul 5	3110154
Pyruvate : NADP+ oxidoreductase from the mitochondrion of Euglena gracilis and from the apicomplexan Cryptosporidium parvum: a biochemical relic linking pyruvate metabolism in mitochondriate and amitochondriate protists.	Rotte C, Stejskal F, Zhu G, Keithly JS, Martin W	2001 May	11319255