EC number:1.2.1.60
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.60 |
|---|---|
| Description: | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase. |
| Alternative Name: |
Carboxymethylhydroxymuconic semialdehyde dehydrogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.60 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.60 |
| KEGG Enzyme Link: | KEGG1.2.1.60 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.60 |
| ExPASy Enzyme Link: | ExPASy1.2.1.60 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.60 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.60 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.60 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.60 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.60 |
| RHEA:15681 | 2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) = (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Catabolism of 3- and 4-hydroxyphenylacetate by the 3,4-dihydroxyphenylacetate pathway in Escherichia coli. | Cooper RA, Skinner MA | 1980 Jul | 6995433 |
| Carboxymethylhydroxymuconic semialdehyde dehydrogenase in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli. | Alonso JM, Garrido-Pertierra A | 1982 Oct 28 | 6756482 |
| The catabolism of L-tyrosine by an Arthrobacter sp. | Blakley ER | 1977 Sep | 20216 |
| Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli. | Garrido-Peritierra A, Cooper RA | 1981 Jul | 7026235 |