EC number:1.2.1.75
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.75 |
|---|---|
| Description: | Malonyl CoA reductase (malonate semialdehyde-forming). |
| Alternative Name: |
NADP-dependent malonyl CoA reductase. Malonyl CoA reductase (NADP). |
| Cath: | 3.30.360.10; 3.40.50.720; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.75 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.75 |
| KEGG Enzyme Link: | KEGG1.2.1.75 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.75 |
| ExPASy Enzyme Link: | ExPASy1.2.1.75 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.75 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.75 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.75 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.75 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.75 |
| RHEA:26446 | 3-oxopropanoate + CoA + NADP(+) = H(+) + malonyl-CoA + NADPH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[c;H0;+0:4]1:[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[n+;H0:8](-[*:9]):[cH;+0:10]:1.[*:11]=[CH;+0:12]-[*:13]>>[*:3]-[C;H0;+0:4]1=[CH;+0:10]-[N;H0;+0:8](-[*:9])-[CH;+0:7]=[CH;+0:6]-[CH2;+0:5]-1.[*:1]-[S;H0;+0:2]-[C;H0;+0:12](=[*:11])-[*:13] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle. | Strauss G, Fuchs G | 1993 Aug 1 | 8354269 |
| Structural basis for a bispecific NADP+ and CoA binding site in an archaeal malonyl-coenzyme A reductase. | Demmer U, Warkentin E, Srivastava A, Kockelkorn D, Pötter M, Marx A, Fuchs G, Ermler U | 2013 Mar 1 | 23325803 |
| A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea. | Berg IA, Kockelkorn D, Buckel W, Fuchs G | 2007 Dec 14 | 18079405 |
| Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp. | Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G | 2006 Dec | 17041055 |
| Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation. | Hügler M, Menendez C, Schägger H, Fuchs G | 2002 May | 11948153 |