EC number:1.2.1.76

Enzyme

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     1. Oxidoreductases
        1.2 Acting on the aldehyde or oxo group of donors
            1.2.1 With NAD+ or NADP+ as acceptor
ID:1.2.1.76
Description:Succinate-semialdehyde dehydrogenase (acetylating).
Alternative Name: Succinyl-CoA reductase.
Coenzyme-A-dependent succinate-semialdehyde dehydrogenase.
Prosite: PDOC00058;
PDB:
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3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.2.1.76
BRENDA Enzyme Link: BRENDA 1.2.1.76
KEGG Enzyme Link: KEGG1.2.1.76
BioCyc Enzyme Link: BioCyc 1.2.1.76
ExPASy Enzyme Link: ExPASy1.2.1.76
EC2PDB Enzyme Link: EC2PDB 1.2.1.76
ExplorEnz Enzyme Link: ExplorEnz 1.2.1.76
PRIAM enzyme-specific profiles Link: PRIAM 1.2.1.76
IntEnz Enzyme Link: IntEnz 1.2.1.76
MEDLINE Enzyme Link: MEDLINE 1.2.1.76

EC number:1.2.1.76

MSA:

1.2.1.76;
Phylogenetic Tree:

1.2.1.76;
Uniprot:
M-CSA:
RHEA:26450 CoA + NADP(+) + succinate semialdehyde = H(+) + NADPH + succinyl-CoA
RULE(radius=1) [*:1]-[SH;+0:2].[*:3]-[c;H0;+0:4]1:[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[n+;H0:8](-[*:9]):[cH;+0:10]:1.[*:11]=[CH;+0:12]-[*:13]>>[*:3]-[C;H0;+0:4]1=[CH;+0:10]-[N;H0;+0:8](-[*:9])-[CH;+0:7]=[CH;+0:6]-[CH2;+0:5]-1.[*:1]-[S;H0;+0:2]-[C;H0;+0:12](=[*:11])-[*:13]
Reaction
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References

TitleAuthorsDatePubMed ID
Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri.Söhling B, Gottschalk G1993 Feb 158444151
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.Berg IA, Kockelkorn D, Buckel W, Fuchs G2007 Dec 1418079405
Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp.Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G2006 Dec17041055