EC number:1.2.1.79
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.79 |
|---|---|
| Description: | Succinate-semialdehyde dehydrogenase (NADP(+)). |
| Cath: | 3.40.605.10; 3.40.309.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.79 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.79 |
| KEGG Enzyme Link: | KEGG1.2.1.79 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.79 |
| ExPASy Enzyme Link: | ExPASy1.2.1.79 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.79 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.79 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.79 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.79 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.79 |
| RHEA:13213 | H2O + NADP(+) + succinate semialdehyde = 2 H(+) + NADPH + succinate |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD). | Bartsch K, von Johnn-Marteville A, Schulz A | 1990 Dec | 2254272 |
| Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases. | Jaeger M, Rothacker B, Ilg T | 2008 Aug 1 | 18474219 |
| Computational prediction and experimental verification of the gene encoding the NAD+/NADP+-dependent succinate semialdehyde dehydrogenase in Escherichia coli. | Fuhrer T, Chen L, Sauer U, Vitkup D | 2007 Nov | 17873044 |
| Final steps in the catabolism of nicotine. | Chiribau CB, Mihasan M, Ganas P, Igloi GL, Artenie V, Brandsch R | 2006 Apr | 16689938 |