EC number:1.2.1.8
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.8 | ||
|---|---|---|---|
| Description: | Betaine-aldehyde dehydrogenase. | ||
| Alternative Name: |
Betaine aldehyde oxidase. Betaine aldehyde dehydrogenase. BADH. | ||
| Prosite: | PDOC00068; | ||
| PDB: |
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| Cath: | 1.10.1220.110; 3.30.410.40; 4.10.450.10; 3.40.605.10; 3.50.50.60; 3.40.309.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.8 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.8 |
| KEGG Enzyme Link: | KEGG1.2.1.8 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.8 |
| ExPASy Enzyme Link: | ExPASy1.2.1.8 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.8 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.8 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.8 |
| RHEA:15305 | betaine aldehyde + H2O + NAD(+) = betaine + 2 H(+) + NADH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structure of betaine aldehyde dehydrogenase at 2.1 A resolution. | Johansson K, El-Ahmad M, Ramaswamy S, Hjelmqvist L, Jörnvall H, Eklund H | 1998 Oct | 9792097 |
| Choline-glycine betaine pathway confers a high level of osmotic tolerance in Escherichia coli. | Landfald B, Strøm AR | 1986 Mar | 3512525 |
| Purification and characterization of osmoregulatory betaine aldehyde dehydrogenase of Escherichia coli. | Falkenberg P, Strøm AR | 1990 Jun 20 | 2194570 |
| Inactivation of an aminoaldehyde dehydrogenase is responsible for fragrance in rice. | Bradbury LM, Gillies SA, Brushett DJ, Waters DL, Henry RJ | 2008 Nov | 18704694 |
| Purification and properties of betaine aldehyde dehydrogenase from Avena sativa. | Livingstone JR, Maruo T, Yoshida I, Tarui Y, Hirooka K, Yamamoto Y, Tsutui N, Hirasawa E | 2003 Apr | 12736784 |
| Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica. | Waditee R, Tanaka Y, Aoki K, Hibino T, Jikuya H, Takano J, Takabe T, Takabe T | 2003 Feb 14 | 12466265 |