EC number:1.2.1.90
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.90 |
|---|---|
| Description: | Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)). |
| Alternative Name: |
Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase. GAPN. |
| Cath: | 3.40.605.10; 3.40.309.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.90 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.90 |
| KEGG Enzyme Link: | KEGG1.2.1.90 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.90 |
| ExPASy Enzyme Link: | ExPASy1.2.1.90 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.90 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.90 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.90 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.90 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.90 |
| RHEA:42760 | D-glyceraldehyde 3-phosphate + H2O + NAD(+) = 3-phospho-D-glycerate + 2 H(+) + NADH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties. | Brunner NA, Brinkmann H, Siebers B, Hensel R | 1998 Mar 13 | 9497334 |
| Characterization of two D-glyceraldehyde-3-phosphate dehydrogenases from the extremely thermophilic archaebacterium Thermoproteus tenax. | Hensel R, Laumann S, Lang J, Heumann H, Lottspeich F | 1987 Dec 30 | 3121324 |
| The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation. | Ahmed H, Ettema TJ, Tjaden B, Geerling AC, van der Oost J, Siebers B | 2005 Sep 1 | 15869466 |
| The crystal structure of the allosteric non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeum Thermoproteus tenax. | Pohl E, Brunner N, Wilmanns M, Hensel R | 2002 May 31 | 11842090 |
| Role of two different glyceraldehyde-3-phosphate dehydrogenases in controlling the reversible Embden-Meyerhof-Parnas pathway in Thermoproteus tenax: regulation on protein and transcript level. | Brunner NA, Siebers B, Hensel R | 2001 Apr | 11354453 |
| RHEA:14669 | D-glyceraldehyde 3-phosphate + H2O + NADP(+) = 3-phospho-D-glycerate + 2 H(+) + NADPH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties. | Brunner NA, Brinkmann H, Siebers B, Hensel R | 1998 Mar 13 | 9497334 |
| Characterization of two D-glyceraldehyde-3-phosphate dehydrogenases from the extremely thermophilic archaebacterium Thermoproteus tenax. | Hensel R, Laumann S, Lang J, Heumann H, Lottspeich F | 1987 Dec 30 | 3121324 |
| The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation. | Ahmed H, Ettema TJ, Tjaden B, Geerling AC, van der Oost J, Siebers B | 2005 Sep 1 | 15869466 |
| Structural Basis of allosteric regulation and substrate specificity of the non-phosphorylating glyceraldehyde 3-Phosphate dehydrogenase from Thermoproteus tenax. | Lorentzen E, Hensel R, Knura T, Ahmed H, Pohl E | 2004 Aug 13 | 15288789 |
| The crystal structure of the allosteric non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeum Thermoproteus tenax. | Pohl E, Brunner N, Wilmanns M, Hensel R | 2002 May 31 | 11842090 |