EC number:1.2.1.99
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.2.1.99 |
|---|---|
| Description: | 4-(gamma-glutamylamino)butanal dehydrogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.1.99 |
| BRENDA Enzyme Link: | BRENDA 1.2.1.99 |
| KEGG Enzyme Link: | KEGG1.2.1.99 |
| BioCyc Enzyme Link: | BioCyc 1.2.1.99 |
| ExPASy Enzyme Link: | ExPASy1.2.1.99 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.1.99 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.1.99 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.1.99 |
| IntEnz Enzyme Link: | IntEnz 1.2.1.99 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.1.99 |
| RHEA:42340 | 4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. | Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H | 2005 Feb 11 | 15590624 |
| RHEA:28410 | 4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[*:11].[OH2;+0:12]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Pathway and enzyme redundancy in putrescine catabolism in Escherichia coli. | Schneider BL, Reitzer L | 2012 Aug | 22636776 |
| Cloning, expression, and characterization of an aldehyde dehydrogenase from Escherichia coli K-12 that utilizes 3-Hydroxypropionaldehyde as a substrate. | Jo JE, Mohan Raj S, Rathnasingh C, Selvakumar E, Jung WC, Park S | 2008 Nov | 18668238 |