EC number:1.2.1.n2
| ID: | 1.2.1.n2 |
|---|---|
| Description: | Fatty acyl-CoA reductase. |
| Alternative Name: |
Hexadecanal dehydrogenase (acylating, NADP dependent). |
3D structure
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| RHEA:36303 | an acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[S;H0;+0:4]-[*:5].[*:6]-[C;H0;+0:7]1=[CH;+0:8]-[N;H0;+0:9](-[*:10])-[CH;+0:11]=[CH;+0:12]-[CH2;+0:13]-1.[*:14]-[C;H0;+0:15]1=[CH;+0:16]-[N;H0;+0:17](-[*:18])-[CH;+0:19]=[CH;+0:20]-[CH2;+0:21]-1.[H+;H0:22].[H+;H0:23]>>[*:1]-[CH2;+0:2]-[OH;+0:3].[*:5]-[SH;+0:4].[*:6]-[c;H0;+0:7]1:[cH;+0:8]:[n+;H0:9](-[*:10]):[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:1.[*:14]-[c;H0;+0:15]1:[cH;+0:16]:[n+;H0:17](-[*:18]):[cH;+0:19]:[cH;+0:20]:[cH;+0:21]:1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. | Cheng JB, Russell DW | 2004 Sep 3 | 15220348 |
| RHEA:27270 | CoA + hexadecanal + NADP(+) = H(+) + hexadecanoyl-CoA + NADPH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[c;H0;+0:4]1:[cH;+0:5]:[cH;+0:6]:[cH;+0:7]:[n+;H0:8](-[*:9]):[cH;+0:10]:1.[*:11]=[CH;+0:12]-[*:13]>>[*:3]-[C;H0;+0:4]1=[CH;+0:10]-[N;H0;+0:8](-[*:9])-[CH;+0:7]=[CH;+0:6]-[CH2;+0:5]-1.[*:1]-[S;H0;+0:2]-[C;H0;+0:12](=[*:11])-[*:13] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| CER4 encodes an alcohol-forming fatty acyl-coenzyme A reductase involved in cuticular wax production in Arabidopsis. | Rowland O, Zheng H, Hepworth SR, Lam P, Jetter R, Kunst L | 2006 Nov | 16980563 |
| Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. | Cheng JB, Russell DW | 2004 Sep 3 | 15220349 |
| Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. | Cheng JB, Russell DW | 2004 Sep 3 | 15220348 |