EC number:1.2.5.1

Enzyme

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     1. Oxidoreductases
        1.2 Acting on the aldehyde or oxo group of donors
            1.2.5 With a quinone or similar compound as acceptor
ID:1.2.5.1
Description:Pyruvate dehydrogenase (quinone).
Alternative Name: Pyruvate oxidase.
Pyruvate dehydrogenase (cytochrome).
Pyruvate dehydrogenase.
Cath: 3.40.50.970; 3.40.50.1220;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.2.5.1
BRENDA Enzyme Link: BRENDA 1.2.5.1
KEGG Enzyme Link: KEGG1.2.5.1
BioCyc Enzyme Link: BioCyc 1.2.5.1
ExPASy Enzyme Link: ExPASy1.2.5.1
EC2PDB Enzyme Link: EC2PDB 1.2.5.1
ExplorEnz Enzyme Link: ExplorEnz 1.2.5.1
PRIAM enzyme-specific profiles Link: PRIAM 1.2.5.1
IntEnz Enzyme Link: IntEnz 1.2.5.1
MEDLINE Enzyme Link: MEDLINE 1.2.5.1

EC number:1.2.5.1

MSA:

1.2.5.1;
Phylogenetic Tree:

1.2.5.1;
Uniprot:
M-CSA:
RHEA:27405 a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2
RULE(radius=1) [*:1]-[C;H0;+0:2](-[CH3;+0:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[C;H0;+0:7](-[*:8])-[C;H0;+0:9](=[O;H0;+0:10])-[C;H0;+0:11](-[*:12])=[C;H0;+0:13](-[*:14])-[C;H0;+0:15]-1=[O;H0;+0:16].[OH2;+0:17]>>[*:1]-[CH3;+0:2].[*:5]-[c;H0;+0:6]1:[c;H0;+0:7](-[*:8]):[c;H0;+0:9](-[OH;+0:10]):[c;H0;+0:11](-[*:12]):[c;H0;+0:13](-[*:14]):[c;H0;+0:15]:1-[OH;+0:16].[O;H0;+0:4]=[C;H0;+0:3]=[O;H0;+0:17]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Role of flavin in acetoin production by two bacterial pyruvate oxidases.Bertagnolli BL, Hager LP1993 Jan8424670
Reconstitution of native Escherichia coli pyruvate oxidase from apoenzyme monomers and FAD.Recny MA, Hager LP1982 Nov 106752142
Role of the tetrameric structure of Escherichia coli pyruvate oxidase in enzyme activation and lipid binding.Wang AY, Chang YY, Cronan JE Jr1991 Jun 152040613