Enzyme

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     1. Oxidoreductases
        1.2 Acting on the aldehyde or oxo group of donors
            1.2.7 With an iron-sulfur protein as acceptor
ID:1.2.7.12
Description:Formylmethanofuran dehydrogenase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.2.7.12
BRENDA Enzyme Link: BRENDA 1.2.7.12
KEGG Enzyme Link: KEGG1.2.7.12
BioCyc Enzyme Link: BioCyc 1.2.7.12
ExPASy Enzyme Link: ExPASy1.2.7.12
EC2PDB Enzyme Link: EC2PDB 1.2.7.12
ExplorEnz Enzyme Link: ExplorEnz 1.2.7.12
PRIAM enzyme-specific profiles Link: PRIAM 1.2.7.12
IntEnz Enzyme Link: IntEnz 1.2.7.12
MEDLINE Enzyme Link: MEDLINE 1.2.7.12
MSA:

1.2.7.12;

Phylogenetic Tree:

1.2.7.12;

Uniprot:
M-CSA:
RHEA:19841 H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]
RULE(radius=1) [*:1]-[Fe+;H0:2]-[*:3].[*:4]-[Fe+;H0:5]-[*:6].[*:7]=[CH;+0:8]-[NH;+0:9]-[*:10].[OH2;+0:11]>>[*:1]-[Fe;H0;+0:2]-[*:3].[*:4]-[Fe;H0;+0:5]-[*:6].[*:10]-[NH2;+0:9].[*:7]=[C;H0;+0:8]=[O;H0;+0:11]
Reaction
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References

TitleAuthorsDatePubMed ID
The active species of 'CO2' utilized by formylmethanofuran dehydrogenase from methanogenic Archaea.Vorholt JA, Thauer RK1997 Sep 159342247
Tungstate can substitute for molybdate in sustaining growth of Methanobacterium thermoautotrophicum. Identification and characterization of a tungsten isoenzyme of formylmethanofuran dehydrogenase.Bertram PA, Schmitz RA, Linder D, Thauer RK19948161283
Formylmethanofuran dehydrogenases from methanogenic Archaea. Substrate specificity, EPR properties and reversible inactivation by cyanide of the molybdenum or tungsten iron-sulfur proteins.Bertram PA, Karrasch M, Schmitz RA, Böcher R, Albracht SP, Thauer RK1994 Mar 18125106
The molybdoenzyme formylmethanofuran dehydrogenase from Methanosarcina barkeri contains a pterin cofactor.Karrasch M, Börner G, Enssle M, Thauer RK1990 Dec 122125267