EC number:1.2.7.3
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.2 Acting on the aldehyde or oxo group of donors |
| 1.2.7 With an iron-sulfur protein as acceptor |
| ID: | 1.2.7.3 |
|---|---|
| Description: | 2-oxoglutarate synthase. |
| Alternative Name: |
KGOR. Alpha-ketoglutarate-ferredoxin oxidoreductase. Alpha-ketoglutarate synthase. 2-oxoglutarate ferredoxin oxidoreductase. 2-ketoglutarate ferredoxin oxidoreductase. |
| Cath: | 3.30.70.20; 4.10.780.10; 4.10.790.10; 3.40.50.920; 3.40.50.970; 3.40.920.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.2.7.3 |
| BRENDA Enzyme Link: | BRENDA 1.2.7.3 |
| KEGG Enzyme Link: | KEGG1.2.7.3 |
| BioCyc Enzyme Link: | BioCyc 1.2.7.3 |
| ExPASy Enzyme Link: | ExPASy1.2.7.3 |
| EC2PDB Enzyme Link: | EC2PDB 1.2.7.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.2.7.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.2.7.3 |
| IntEnz Enzyme Link: | IntEnz 1.2.7.3 |
| MEDLINE Enzyme Link: | MEDLINE 1.2.7.3 |
| RHEA:17297 | 2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA |
| RULE(radius=1) | [*:1]-[Fe+;H0:2]-[*:3].[*:4]-[Fe+;H0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[OH;+0:11])-[C;H0;+0:12](=[*:13])-[*:14]>>[*:1]-[Fe;H0;+0:2]-[*:3].[*:4]-[Fe;H0;+0:5]-[*:6].[*:13]=[C;H0;+0:12](-[*:14])-[S;H0;+0:8]-[*:7].[*:9]=[C;H0;+0:10]=[O;H0;+0:11] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of a fourth type of 2-keto acid-oxidizing enzyme from a hyperthermophilic archaeon: 2-ketoglutarate ferredoxin oxidoreductase from Thermococcus litoralis. | Mai X, Adams MW | 1996 Oct | 8830683 |
| Purification and properties of -ketoglutarate synthase from a photosynthetic bacterium. | Gehring U, Arnon DI | 1972 Nov 10 | 4628267 |
| The synthesis of alpha-ketoglutarate from succinate and carbon dioxide by a subcellular preparation of a photosynthetic bacterium. | Buchanan BB, Evans MC | 1965 Oct | 4286833 |
| 2-keto acid oxidoreductases from Pyrococcus furiosus and Thermococcus litoralis. | Schut GJ, Menon AL, Adams MW | 2001 | 11265457 |