EC number:1.2.7.7

Enzyme

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EC Tree
     1. Oxidoreductases
        1.2 Acting on the aldehyde or oxo group of donors
            1.2.7 With an iron-sulfur protein as acceptor
ID:1.2.7.7
Description:3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).
Alternative Name: VOR.
Ketoisovalerate oxidoreductase.
Ketoisovalerate ferredoxin reductase.
Keto-valine-ferredoxin oxidoreductase.
Branched-chain oxo acid ferredoxin reductase.
Branched-chain ketoacid ferredoxin reductase.
3-methyl-2-oxobutanoate synthase (ferredoxin).
2-oxoisovalerate ferredoxin reductase.
2-ketoisovalerate ferredoxin reductase.
Cath: 3.30.70.20; 4.10.780.10; 4.10.790.10; 3.40.50.920; 3.40.50.970; 3.40.920.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.2.7.7
BRENDA Enzyme Link: BRENDA 1.2.7.7
KEGG Enzyme Link: KEGG1.2.7.7
BioCyc Enzyme Link: BioCyc 1.2.7.7
ExPASy Enzyme Link: ExPASy1.2.7.7
EC2PDB Enzyme Link: EC2PDB 1.2.7.7
ExplorEnz Enzyme Link: ExplorEnz 1.2.7.7
PRIAM enzyme-specific profiles Link: PRIAM 1.2.7.7
IntEnz Enzyme Link: IntEnz 1.2.7.7
MEDLINE Enzyme Link: MEDLINE 1.2.7.7

EC number:1.2.7.7

MSA:

1.2.7.7;
Phylogenetic Tree:

1.2.7.7;
Uniprot:
M-CSA:
RHEA:11712 3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
RULE(radius=1) [*:1]-[Fe+;H0:2]-[*:3].[*:4]-[Fe+;H0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[OH;+0:11])-[C;H0;+0:12](=[*:13])-[*:14]>>[*:1]-[Fe;H0;+0:2]-[*:3].[*:4]-[Fe;H0;+0:5]-[*:6].[*:13]=[C;H0;+0:12](-[*:14])-[S;H0;+0:8]-[*:7].[*:9]=[C;H0;+0:10]=[O;H0;+0:11]
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References

TitleAuthorsDatePubMed ID
Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum.Tersteegen A, Linder D, Thauer RK, Hedderich R1997 Mar 159108258
Characterization of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A-dependent enzyme involved in peptide fermentation by hyperthermophilic archaea.Heider J, Mai X, Adams MW1996 Feb8550513
Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.Kletzin A, Adams MW1996 Jan8550425