EC number:1.21.1.1
| ID: | 1.21.1.1 |
|---|---|
| Description: | Iodotyrosine deiodinase. |
| Alternative Name: |
Iodotyrosine dehalogenase 1. |
| Cath: | 3.40.109.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.21.1.1 |
| BRENDA Enzyme Link: | BRENDA 1.21.1.1 |
| KEGG Enzyme Link: | KEGG1.21.1.1 |
| BioCyc Enzyme Link: | BioCyc 1.21.1.1 |
| ExPASy Enzyme Link: | ExPASy1.21.1.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.21.1.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.21.1.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.21.1.1 |
| IntEnz Enzyme Link: | IntEnz 1.21.1.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.21.1.1 |
| RHEA:32479 | 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH |
| RULE(radius=1) | [*:1]-[c;H0;+0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[n+;H0:6](-[*:7]):[cH;+0:8]:1.[*:9]-[n+;H0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[*:15]):[cH;+0:16]:1.[*:17]:[cH;+0:18]:[*:19]:[cH;+0:20]:[*:21].[I-;H0:22].[I-;H0:23]>>[*:1]-[C;H0;+0:2]1=[CH;+0:8]-[N;H0;+0:6](-[*:7])-[CH;+0:5]=[CH;+0:4]-[CH2;+0:3]-1.[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[CH;+0:12]-[CH2;+0:13]-[C;H0;+0:14](-[*:15])=[CH;+0:16]-1.[*:17]:[c;H0;+0:18](-[I;H0;+0:22]):[*:19]:[c;H0;+0:20](:[*:21])-[I;H0;+0:23] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification of iodotyrosine deiodinase from bovine thyroid. | Rosenberg IN | 1970 Oct | 4394169 |
| A switch between one- and two-electron chemistry of the human flavoprotein iodotyrosine deiodinase is controlled by substrate. | Hu J, Chuenchor W, Rokita SE | 2015 Jan 2 | 25395621 |
| Expression of a soluble form of iodotyrosine deiodinase for active site characterization by engineering the native membrane protein from Mus musculus. | Buss JM, McTamney PM, Rokita SE | 2012 Mar | 22238141 |
| Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands. | Thomas SR, McTamney PM, Adler JM, Laronde-Leblanc N, Rokita SE | 2009 Jul 17 | 19436071 |
| Mutations in the iodotyrosine deiodinase gene and hypothyroidism. | Moreno JC, Klootwijk W, van Toor H, Pinto G, D'Alessandro M, Lèger A, Goudie D, Polak M, Grüters A, Visser TJ | 2008 Apr 24 | 18434651 |
| Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily. | Friedman JE, Watson JA Jr, Lam DW, Rokita SE | 2006 Feb 3 | 16316988 |
| Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site. | Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noël-Hudson MS, Morand S, Agnangji D, Sezan A, Courtin F, Virion A, Dupuy C | 2004 Oct | 15289438 |