EC number:1.21.3.3

Enzyme

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EC Tree
     1. Oxidoreductases
        1.21 Catalysing the reaction X-H + Y-H = X-Y
            1.21.3 With oxygen as acceptor
ID:1.21.3.3
Description:Reticuline oxidase.
Alternative Name: Tetrahydroprotoberberine synthase.
Berberine-bridge-forming enzyme.
Berberine bridge enzyme.
Prosite: PDOC00674;
PDB:
PDBScop
Cath: 3.30.43.10; 3.30.465.50; 3.40.462.20;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.21.3.3
BRENDA Enzyme Link: BRENDA 1.21.3.3
KEGG Enzyme Link: KEGG1.21.3.3
BioCyc Enzyme Link: BioCyc 1.21.3.3
ExPASy Enzyme Link: ExPASy1.21.3.3
EC2PDB Enzyme Link: EC2PDB 1.21.3.3
ExplorEnz Enzyme Link: ExplorEnz 1.21.3.3
PRIAM enzyme-specific profiles Link: PRIAM 1.21.3.3
IntEnz Enzyme Link: IntEnz 1.21.3.3
MEDLINE Enzyme Link: MEDLINE 1.21.3.3

EC number:1.21.3.3

MSA:

1.21.3.3;
Phylogenetic Tree:

1.21.3.3;
Uniprot:
M-CSA:
RHEA:19885 (S)-reticuline + O2 = (S)-scoulerine + H(+) + H2O2
RULE(radius=1) ([*:1]-[CH3;+0:2].[*:3]:[cH;+0:4]:[*:5]).[O;H0;+0:6]=[O;H0;+0:7]>>[*:1]-[CH2;+0:2]-[c;H0;+0:4](:[*:3]):[*:5].[OH;+0:6]-[OH;+0:7]
Reaction
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References

TitleAuthorsDatePubMed ID
Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants.Kutchan TM, Dittrich H1995 Oct 137592663
Molecular cloning, expression, and induction of berberine bridge enzyme, an enzyme essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack.Dittrich H, Kutchan TM1991 Nov 151946465
Structural and mechanistic studies reveal the functional role of bicovalent flavinylation in berberine bridge enzyme.Winkler A, Motz K, Riedl S, Puhl M, Macheroux P, Gruber K2009 Jul 2419457868