EC number:1.21.3.7
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.21 Catalysing the reaction X-H + Y-H = X-Y |
| 1.21.3 With oxygen as acceptor |
| ID: | 1.21.3.7 |
|---|---|
| Description: | Tetrahydrocannabinolic acid synthase. |
| Alternative Name: |
THCA synthase. Delta(1)-tetrahydrocannabinolic acid synthase. |
| Cath: | 3.30.43.10; 3.30.465.50; 3.40.462.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.21.3.7 |
| BRENDA Enzyme Link: | BRENDA 1.21.3.7 |
| KEGG Enzyme Link: | KEGG1.21.3.7 |
| BioCyc Enzyme Link: | BioCyc 1.21.3.7 |
| ExPASy Enzyme Link: | ExPASy1.21.3.7 |
| EC2PDB Enzyme Link: | EC2PDB 1.21.3.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.21.3.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.21.3.7 |
| IntEnz Enzyme Link: | IntEnz 1.21.3.7 |
| MEDLINE Enzyme Link: | MEDLINE 1.21.3.7 |
| RHEA:34143 | cannabinerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2 |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3]:[*:4]-[OH;+0:5].[*:6]-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[*:10]).[O;H0;+0:11]=[O;H0;+0:12]>>[*:1]-[CH;+0:2]1-[*:3]:[*:4]-[O;H0;+0:5]-[C;H0;+0:8](-[*:9])(-[*:10])-[CH;+0:7]-1-[*:6].[OH;+0:11]-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Delta1-tetrahydrocannabinolic acid synthase from Cannabis sativa L. | Sirikantaramas S, Morimoto S, Shoyama Y, Ishikawa Y, Wada Y, Shoyama Y, Taura F | 2004 Sep 17 | 15190053 |
| RHEA:34135 | cannabigerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2 |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3]:[*:4]-[OH;+0:5].[*:6]-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[*:10]).[O;H0;+0:11]=[O;H0;+0:12]>>[*:1]-[CH;+0:2]1-[*:3]:[*:4]-[O;H0;+0:5]-[C;H0;+0:8](-[*:9])(-[*:10])-[CH;+0:7]-1-[*:6].[OH;+0:11]-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structure and function of ∆1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa. | Shoyama Y, Tamada T, Kurihara K, Takeuchi A, Taura F, Arai S, Blaber M, Shoyama Y, Morimoto S, Kuroki R | 2012 Oct 12 | 22766313 |
| Production of Delta(1)-tetrahydrocannabinolic acid by the biosynthetic enzyme secreted from transgenic Pichia pastoris. | Taura F, Dono E, Sirikantaramas S, Yoshimura K, Shoyama Y, Morimoto S | 2007 Sep 28 | 17669365 |
| Crystallization of Delta1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa. | Shoyama Y, Takeuchi A, Taura F, Tamada T, Adachi M, Kuroki R, Shoyama Y, Morimoto S | 2005 Aug 1 | 16511162 |
| The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Delta1-tetrahydrocannabinolic acid synthase from Cannabis sativa L. | Sirikantaramas S, Morimoto S, Shoyama Y, Ishikawa Y, Wada Y, Shoyama Y, Taura F | 2004 Sep 17 | 15190053 |