EC number:1.21.98.2

Enzyme

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     1. Oxidoreductases
        1.21 Catalysing the reaction X-H + Y-H = X-Y
            1.21.98 With other, known, physiological acceptors
ID:1.21.98.2
Description:Dichlorochromopyrrolate synthase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.21.98.2
BRENDA Enzyme Link: BRENDA 1.21.98.2
KEGG Enzyme Link: KEGG1.21.98.2
BioCyc Enzyme Link: BioCyc 1.21.98.2
ExPASy Enzyme Link: ExPASy1.21.98.2
EC2PDB Enzyme Link: EC2PDB 1.21.98.2
ExplorEnz Enzyme Link: ExplorEnz 1.21.98.2
PRIAM enzyme-specific profiles Link: PRIAM 1.21.98.2
IntEnz Enzyme Link: IntEnz 1.21.98.2
MEDLINE Enzyme Link: MEDLINE 1.21.98.2

EC number:1.21.98.2

MSA:

1.21.98.2;
Phylogenetic Tree:

1.21.98.2;
Uniprot:
M-CSA:
RHEA:50920 2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = chromopyrrolate + H(+) + 2 H2O + NH4(+)
RULE(radius=1) [*:1]-[C;H0;+0:2](=[NH;+0:3])-[CH2;+0:4]-[c;H0;+0:5](:[*:6]):[*:7].[*:8]:[c;H0;+0:9](:[*:10])-[CH2;+0:11]-[C;H0;+0:12](-[*:13])=[NH;+0:14].[OH;+0:15]-[OH;+0:16]>>[*:8]:[c;H0;+0:9](:[*:10])-[c;H0;+0:11]1:[c;H0;+0:4](-[c;H0;+0:5](:[*:6]):[*:7]):[c;H0;+0:2](-[*:1]):[nH;+0:14]:[c;H0;+0:12]:1-[*:13].[NH3;+0:3].[OH2;+0:15].[OH2;+0:16]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum.Balibar CJ, Walsh CT2006 Dec 2617176066
Evidence for catalytic intermediates involved in generating the chromopyrrolic acid scaffold of rebeccamycin by RebO and RebD.Spolitak T, Ballou DP2015 May 125837855
Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD.Howard-Jones AR, Walsh CT2005 Dec 616313168
RHEA:27393 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)
RULE(radius=1) [*:1]-[C;H0;+0:2](=[NH;+0:3])-[CH2;+0:4]-[c;H0;+0:5](:[*:6]):[*:7].[*:8]:[c;H0;+0:9](:[*:10])-[CH2;+0:11]-[C;H0;+0:12](-[*:13])=[NH;+0:14].[OH;+0:15]-[OH;+0:16]>>[*:8]:[c;H0;+0:9](:[*:10])-[c;H0;+0:11]1:[c;H0;+0:4](-[c;H0;+0:5](:[*:6]):[*:7]):[c;H0;+0:2](-[*:1]):[nH;+0:14]:[c;H0;+0:12]:1-[*:13].[NH3;+0:3].[OH2;+0:15].[OH2;+0:16]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Evidence for catalytic intermediates involved in generating the chromopyrrolic acid scaffold of rebeccamycin by RebO and RebD.Spolitak T, Ballou DP2015 May 125837855
Enzymatic assembly of the bis-indole core of rebeccamycin.Nishizawa T, Grüschow S, Jayamaha DH, Nishizawa-Harada C, Sherman DH2006 Jan 2516417354
Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD.Howard-Jones AR, Walsh CT2005 Dec 616313168