EC number:1.3.1.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.1 |
|---|---|
| Description: | Dihydrouracil dehydrogenase (NAD(+)). |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.1 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.1 |
| KEGG Enzyme Link: | KEGG1.3.1.1 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.1 |
| ExPASy Enzyme Link: | ExPASy1.3.1.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.1 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.1 |
| RHEA:28791 | H(+) + NADH + thymine = 5,6-dihydrothymine + NAD(+) |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[C;H0;+0:10]1-[NH;+0:11]-[C;H0;+0:12](=[*:13])-[CH;+0:14](-[*:15])-[CH2;+0:16]-[NH;+0:17]-1>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[c;H0;+0:10]1:[nH;+0:11]:[c;H0;+0:12](=[*:13]):[c;H0;+0:14](-[*:15]):[cH;+0:16]:[nH;+0:17]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of dihydropyrimidine dehydrogenase from Alcaligenes eutrophus. | Schmitt U, Jahnke K, Rosenbaum K, Cook PF, Schnackerz KD | 1996 Aug 1 | 8806723 |
| Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil. | Hidese R, Mihara H, Kurihara T, Esaki N | 2011 Feb | 21169495 |
| Pyrimidine catabolism in Pseudomonas aeruginosa. | Kim S, West TP | 1991 Jan 15 | 1903745 |
| Reductive degradation of pyrimidines. III. Purification and properties of dihydrouracil dehydrogenase. | CAMPBELL LL Jr | 1957 Aug | 13462991 |
| Pyrimidine base catabolism in Pseudomonas putida biotype B. | West TP | 2001 Oct | 11759049 |
| Isolation and characterization of an Escherichia coli B mutant strain defective in uracil catabolism. | West TP | 1998 Nov | 10030006 |
| RHEA:20189 | 5,6-dihydrouracil + NAD(+) = H(+) + NADH + uracil |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[C;H0;+0:10]1-[NH;+0:11]-[C;H0;+0:12](=[*:13])-[CH2;+0:14]-[CH2;+0:15]-[NH;+0:16]-1>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[c;H0;+0:10]1:[nH;+0:11]:[c;H0;+0:12](=[*:13]):[cH;+0:14]:[cH;+0:15]:[nH;+0:16]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of dihydropyrimidine dehydrogenase from Alcaligenes eutrophus. | Schmitt U, Jahnke K, Rosenbaum K, Cook PF, Schnackerz KD | 1996 Aug 1 | 8806723 |
| Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil. | Hidese R, Mihara H, Kurihara T, Esaki N | 2011 Feb | 21169495 |
| Pyrimidine catabolism in Pseudomonas aeruginosa. | Kim S, West TP | 1991 Jan 15 | 1903745 |
| Reductive degradation of pyrimidines. III. Purification and properties of dihydrouracil dehydrogenase. | CAMPBELL LL Jr | 1957 Aug | 13462991 |
| Pyrimidine base catabolism in Pseudomonas putida biotype B. | West TP | 2001 Oct | 11759049 |
| Isolation and characterization of an Escherichia coli B mutant strain defective in uracil catabolism. | West TP | 1998 Nov | 10030006 |