EC number:1.3.1.101
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.101 |
|---|---|
| Description: | 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (NAD(P)H). |
| Alternative Name: |
Digeranylgeranylglycerophospholipid reductase. DGGGPL reductase. 2,3-digeranylgeranylglycerophospholipid reductase. |
| Cath: | 3.30.9.10; 3.50.50.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.101 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.101 |
| KEGG Enzyme Link: | KEGG1.3.1.101 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.101 |
| ExPASy Enzyme Link: | ExPASy1.3.1.101 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.101 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.101 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.101 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.101 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.101 |
EC number:1.3.1.101
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:36039 | 2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5]-[*:6]-[CH2;+0:7]-[CH;+0:8](-[*:9])-[*:10]-[*:11]-[CH2;+0:12]-[CH;+0:13](-[*:14])-[*:15]-[*:16]-[CH2;+0:17]-[CH;+0:18](-[*:19])-[*:20].[*:21]-[CH;+0:22](-[*:23]-[*:24]-[CH2;+0:25]-[CH;+0:26](-[*:27])-[*:28]-[*:29]-[CH2;+0:30]-[CH;+0:31](-[*:32])-[*:33]-[*:34]-[CH2;+0:35]-[CH;+0:36](-[*:37])-[*:38])-[CH2;+0:39]-[*:40]).[*:41]-[c;H0;+0:42]1:[cH;+0:43]:[cH;+0:44]:[cH;+0:45]:[n+;H0:46](-[*:47]):[cH;+0:48]:1.[*:49]-[c;H0;+0:50]1:[cH;+0:51]:[cH;+0:52]:[cH;+0:53]:[n+;H0:54](-[*:55]):[cH;+0:56]:1.[*:57]-[c;H0;+0:58]1:[cH;+0:59]:[cH;+0:60]:[cH;+0:61]:[n+;H0:62](-[*:63]):[cH;+0:64]:1.[*:65]-[c;H0;+0:66]1:[cH;+0:67]:[cH;+0:68]:[cH;+0:69]:[n+;H0:70](-[*:71]):[cH;+0:72]:1.[*:73]-[c;H0;+0:74]1:[cH;+0:75]:[cH;+0:76]:[cH;+0:77]:[n+;H0:78](-[*:79]):[cH;+0:80]:1.[*:81]-[c;H0;+0:82]1:[cH;+0:83]:[cH;+0:84]:[cH;+0:85]:[n+;H0:86](-[*:87]):[cH;+0:88]:1.[*:89]-[c;H0;+0:90]1:[cH;+0:91]:[cH;+0:92]:[cH;+0:93]:[n+;H0:94](-[*:95]):[cH;+0:96]:1.[*:97]-[n+;H0:98]1:[cH;+0:99]:[cH;+0:100]:[cH;+0:101]:[c;H0;+0:102](-[*:103]):[cH;+0:104]:1>>([*:21]-[C;H0;+0:22](-[*:23]-[*:24]-[CH;+0:25]=[C;H0;+0:26](-[*:27])-[*:28]-[*:29]-[CH;+0:30]=[C;H0;+0:31](-[*:32])-[*:33]-[*:34]-[CH;+0:35]=[C;H0;+0:36](-[*:37])-[*:38])=[CH;+0:39]-[*:40].[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5]-[*:6]-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[*:10]-[*:11]-[CH;+0:12]=[C;H0;+0:13](-[*:14])-[*:15]-[*:16]-[CH;+0:17]=[C;H0;+0:18](-[*:19])-[*:20]).[*:41]-[C;H0;+0:42]1=[CH;+0:48]-[N;H0;+0:46](-[*:47])-[CH;+0:45]=[CH;+0:44]-[CH2;+0:43]-1.[*:49]-[C;H0;+0:50]1=[CH;+0:56]-[N;H0;+0:54](-[*:55])-[CH;+0:53]=[CH;+0:52]-[CH2;+0:51]-1.[*:57]-[C;H0;+0:58]1=[CH;+0:64]-[N;H0;+0:62](-[*:63])-[CH;+0:61]=[CH;+0:60]-[CH2;+0:59]-1.[*:65]-[C;H0;+0:66]1=[CH;+0:72]-[N;H0;+0:70](-[*:71])-[CH;+0:69]=[CH;+0:68]-[CH2;+0:67]-1.[*:73]-[C;H0;+0:74]1=[CH;+0:80]-[N;H0;+0:78](-[*:79])-[CH;+0:77]=[CH;+0:76]-[CH2;+0:75]-1.[*:81]-[C;H0;+0:82]1=[CH;+0:88]-[N;H0;+0:86](-[*:87])-[CH;+0:85]=[CH;+0:84]-[CH2;+0:83]-1.[*:89]-[C;H0;+0:90]1=[CH;+0:96]-[N;H0;+0:94](-[*:95])-[CH;+0:93]=[CH;+0:92]-[CH2;+0:91]-1.[*:97]-[N;H0;+0:98]1-[CH;+0:99]=[CH;+0:100]-[CH2;+0:101]-[C;H0;+0:102](-[*:103])=[CH;+0:104]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids. | Xu Q, Eguchi T, Mathews II, Rife CL, Chiu HJ, Farr CL, Feuerhelm J, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Weekes D, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA | 2010 Dec 3 | 20869368 |
| Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum. | Nishimura Y, Eguchi T | 2006 Jun | 16788058 |
| RHEA:36035 | 2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5]-[*:6]-[CH2;+0:7]-[CH;+0:8](-[*:9])-[*:10]-[*:11]-[CH2;+0:12]-[CH;+0:13](-[*:14])-[*:15]-[*:16]-[CH2;+0:17]-[CH;+0:18](-[*:19])-[*:20].[*:21]-[CH;+0:22](-[*:23]-[*:24]-[CH2;+0:25]-[CH;+0:26](-[*:27])-[*:28]-[*:29]-[CH2;+0:30]-[CH;+0:31](-[*:32])-[*:33]-[*:34]-[CH2;+0:35]-[CH;+0:36](-[*:37])-[*:38])-[CH2;+0:39]-[*:40]).[*:41]-[c;H0;+0:42]1:[cH;+0:43]:[cH;+0:44]:[cH;+0:45]:[n+;H0:46](-[*:47]):[cH;+0:48]:1.[*:49]-[c;H0;+0:50]1:[cH;+0:51]:[cH;+0:52]:[cH;+0:53]:[n+;H0:54](-[*:55]):[cH;+0:56]:1.[*:57]-[c;H0;+0:58]1:[cH;+0:59]:[cH;+0:60]:[cH;+0:61]:[n+;H0:62](-[*:63]):[cH;+0:64]:1.[*:65]-[c;H0;+0:66]1:[cH;+0:67]:[cH;+0:68]:[cH;+0:69]:[n+;H0:70](-[*:71]):[cH;+0:72]:1.[*:73]-[c;H0;+0:74]1:[cH;+0:75]:[cH;+0:76]:[cH;+0:77]:[n+;H0:78](-[*:79]):[cH;+0:80]:1.[*:81]-[c;H0;+0:82]1:[cH;+0:83]:[cH;+0:84]:[cH;+0:85]:[n+;H0:86](-[*:87]):[cH;+0:88]:1.[*:89]-[c;H0;+0:90]1:[cH;+0:91]:[cH;+0:92]:[cH;+0:93]:[n+;H0:94](-[*:95]):[cH;+0:96]:1.[*:97]-[c;H0;+0:98]1:[cH;+0:99]:[cH;+0:100]:[cH;+0:101]:[n+;H0:102](-[*:103]):[cH;+0:104]:1>>([*:21]-[C;H0;+0:22](-[*:23]-[*:24]-[CH;+0:25]=[C;H0;+0:26](-[*:27])-[*:28]-[*:29]-[CH;+0:30]=[C;H0;+0:31](-[*:32])-[*:33]-[*:34]-[CH;+0:35]=[C;H0;+0:36](-[*:37])-[*:38])=[CH;+0:39]-[*:40].[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5]-[*:6]-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[*:10]-[*:11]-[CH;+0:12]=[C;H0;+0:13](-[*:14])-[*:15]-[*:16]-[CH;+0:17]=[C;H0;+0:18](-[*:19])-[*:20]).[*:41]-[C;H0;+0:42]1=[CH;+0:48]-[N;H0;+0:46](-[*:47])-[CH;+0:45]=[CH;+0:44]-[CH2;+0:43]-1.[*:49]-[C;H0;+0:50]1=[CH;+0:56]-[N;H0;+0:54](-[*:55])-[CH;+0:53]=[CH;+0:52]-[CH2;+0:51]-1.[*:57]-[C;H0;+0:58]1=[CH;+0:64]-[N;H0;+0:62](-[*:63])-[CH;+0:61]=[CH;+0:60]-[CH2;+0:59]-1.[*:65]-[C;H0;+0:66]1=[CH;+0:72]-[N;H0;+0:70](-[*:71])-[CH;+0:69]=[CH;+0:68]-[CH2;+0:67]-1.[*:73]-[C;H0;+0:74]1=[CH;+0:80]-[N;H0;+0:78](-[*:79])-[CH;+0:77]=[CH;+0:76]-[CH2;+0:75]-1.[*:81]-[C;H0;+0:82]1=[CH;+0:88]-[N;H0;+0:86](-[*:87])-[CH;+0:85]=[CH;+0:84]-[CH2;+0:83]-1.[*:89]-[C;H0;+0:90]1=[CH;+0:96]-[N;H0;+0:94](-[*:95])-[CH;+0:93]=[CH;+0:92]-[CH2;+0:91]-1.[*:97]-[C;H0;+0:98]1=[CH;+0:104]-[N;H0;+0:102](-[*:103])-[CH;+0:101]=[CH;+0:100]-[CH2;+0:99]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids. | Xu Q, Eguchi T, Mathews II, Rife CL, Chiu HJ, Farr CL, Feuerhelm J, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Weekes D, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA | 2010 Dec 3 | 20869368 |
| Biosynthesis of archaeal membrane lipids: digeranylgeranylglycerophospholipid reductase of the thermoacidophilic archaeon Thermoplasma acidophilum. | Nishimura Y, Eguchi T | 2006 Jun | 16788058 |