EC number:1.3.1.105
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.105 |
|---|---|
| Description: | 2-methylene-furan-3-one reductase. |
| Alternative Name: |
Enone oxidoreductase. |
| Cath: | 3.40.50.720; 3.90.180.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.105 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.105 |
| KEGG Enzyme Link: | KEGG1.3.1.105 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.105 |
| ExPASy Enzyme Link: | ExPASy1.3.1.105 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.105 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.105 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.105 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.105 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.105 |
EC number:1.3.1.105
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:53944 | 2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) = (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH2;+0:4]-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification and characterization of an enzyme involved in the biosynthesis of the 4-hydroxy-2(or 5)-ethyl-5(or 2)-methyl-3(2H)-furanone in yeast. | Uehara K, Watanabe J, Mogi Y, Tsukioka Y | 2017 Mar | 27865643 |
| RHEA:39115 | 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH |
| RULE(radius=1) | [*:1]-[c;H0;+0:2]1:[c;H0;+0:3](-[OH;+0:4]):[c;H0;+0:5](-[CH3;+0:6]):[o;H0;+0:7]:[c;H0;+0:8]:1-[*:9].[*:10]-[n+;H0:11]1:[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:[c;H0;+0:15](-[*:16]):[cH;+0:17]:1>>[*:1]-[C;H0;+0:2]1=[C;H0;+0:8](-[*:9])-[O;H0;+0:7]-[C;H0;+0:5](=[CH2;+0:6])-[C;H0;+0:3]-1=[O;H0;+0:4].[*:10]-[N;H0;+0:11]1-[CH;+0:12]=[CH;+0:13]-[CH2;+0:14]-[C;H0;+0:15](-[*:16])=[CH;+0:17]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification and characterization of an enzyme involved in the biosynthesis of the 4-hydroxy-2(or 5)-ethyl-5(or 2)-methyl-3(2H)-furanone in yeast. | Uehara K, Watanabe J, Mogi Y, Tsukioka Y | 2017 Mar | 27865643 |
| Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone. | Schiefner A, Sinz Q, Neumaier I, Schwab W, Skerra A | 2013 Jun 7 | 23589283 |
| Functional characterization of enone oxidoreductases from strawberry and tomato fruit. | Klein D, Fink B, Arold B, Eisenreich W, Schwab W | 2007 Aug 8 | 17636940 |
| FaQR, required for the biosynthesis of the strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone, encodes an enone oxidoreductase. | Raab T, López-Ráez JA, Klein D, Caballero JL, Moyano E, Schwab W, Muñoz-Blanco J | 2006 Apr | 16517758 |
| RHEA:39111 | 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[c;H0;+0:2]1:[c;H0;+0:3](-[OH;+0:4]):[c;H0;+0:5](-[CH3;+0:6]):[o;H0;+0:7]:[c;H0;+0:8]:1-[*:9].[*:10]-[n+;H0:11]1:[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:[c;H0;+0:15](-[*:16]):[cH;+0:17]:1>>[*:1]-[C;H0;+0:2]1=[C;H0;+0:8](-[*:9])-[O;H0;+0:7]-[C;H0;+0:5](=[CH2;+0:6])-[C;H0;+0:3]-1=[O;H0;+0:4].[*:10]-[N;H0;+0:11]1-[CH;+0:12]=[CH;+0:13]-[CH2;+0:14]-[C;H0;+0:15](-[*:16])=[CH;+0:17]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification and characterization of an enzyme involved in the biosynthesis of the 4-hydroxy-2(or 5)-ethyl-5(or 2)-methyl-3(2H)-furanone in yeast. | Uehara K, Watanabe J, Mogi Y, Tsukioka Y | 2017 Mar | 27865643 |
| Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone. | Schiefner A, Sinz Q, Neumaier I, Schwab W, Skerra A | 2013 Jun 7 | 23589283 |
| Functional characterization of enone oxidoreductases from strawberry and tomato fruit. | Klein D, Fink B, Arold B, Eisenreich W, Schwab W | 2007 Aug 8 | 17636940 |
| FaQR, required for the biosynthesis of the strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone, encodes an enone oxidoreductase. | Raab T, López-Ráez JA, Klein D, Caballero JL, Moyano E, Schwab W, Muñoz-Blanco J | 2006 Apr | 16517758 |