EC number:1.3.1.107

Enzyme

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     1. Oxidoreductases
        1.3 Acting on the CH-CH group of donors
            1.3.1 With NAD+ or NADP+ as acceptor
ID:1.3.1.107
Description:Sanguinarine reductase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.3.1.107
BRENDA Enzyme Link: BRENDA 1.3.1.107
KEGG Enzyme Link: KEGG1.3.1.107
BioCyc Enzyme Link: BioCyc 1.3.1.107
ExPASy Enzyme Link: ExPASy1.3.1.107
EC2PDB Enzyme Link: EC2PDB 1.3.1.107
ExplorEnz Enzyme Link: ExplorEnz 1.3.1.107
PRIAM enzyme-specific profiles Link: PRIAM 1.3.1.107
IntEnz Enzyme Link: IntEnz 1.3.1.107
MEDLINE Enzyme Link: MEDLINE 1.3.1.107

EC number:1.3.1.107

MSA:

1.3.1.107;
Phylogenetic Tree:

1.3.1.107;
Uniprot:
M-CSA:
RHEA:41656 dihydrosanguinarine + NADP(+) = NADPH + sanguinarine
RULE(radius=1) [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[c;H0;+0:10]1:[*:11]-[CH2;+0:12]-[N;H0;+0:13](-[*:14])-[*:15]:[c;H0;+0:16]-1:[*:17]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[c;H0;+0:10]1:[*:11]:[cH;+0:12]:[n+;H0:13](-[*:14]):[*:15]:[c;H0;+0:16]:1:[*:17]
Reaction
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Core-to-Core More

References

TitleAuthorsDatePubMed ID
Structure and mechanism of sanguinarine reductase, an enzyme of alkaloid detoxification.Vogel M, Lawson M, Sippl W, Conrad U, Roos W2010 Jun 1120378534
Sanguinarine reductase, a key enzyme of benzophenanthridine detoxification.Weiss D, Baumert A, Vogel M, Roos W2006 Feb17080644
RHEA:41660 dihydrosanguinarine + NAD(+) = NADH + sanguinarine
RULE(radius=1) [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[c;H0;+0:10]1:[*:11]-[CH2;+0:12]-[N;H0;+0:13](-[*:14])-[*:15]:[c;H0;+0:16]-1:[*:17]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[c;H0;+0:10]1:[*:11]:[cH;+0:12]:[n+;H0:13](-[*:14]):[*:15]:[c;H0;+0:16]:1:[*:17]
Reaction
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Structure and mechanism of sanguinarine reductase, an enzyme of alkaloid detoxification.Vogel M, Lawson M, Sippl W, Conrad U, Roos W2010 Jun 1120378534
Sanguinarine reductase, a key enzyme of benzophenanthridine detoxification.Weiss D, Baumert A, Vogel M, Roos W2006 Feb17080644
RHEA:41664 dihydrochelirubine + NAD(+) = chelirubine + NADH
RULE(radius=1) [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[c;H0;+0:10]1:[*:11]-[CH2;+0:12]-[N;H0;+0:13](-[*:14])-[*:15]:[c;H0;+0:16]-1:[*:17]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[c;H0;+0:10]1:[*:11]:[cH;+0:12]:[n+;H0:13](-[*:14]):[*:15]:[c;H0;+0:16]:1:[*:17]
Reaction
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Structure and mechanism of sanguinarine reductase, an enzyme of alkaloid detoxification.Vogel M, Lawson M, Sippl W, Conrad U, Roos W2010 Jun 1120378534
Sanguinarine reductase, a key enzyme of benzophenanthridine detoxification.Weiss D, Baumert A, Vogel M, Roos W2006 Feb17080644
RHEA:41668 dihydrochelirubine + NADP(+) = chelirubine + NADPH
RULE(radius=1) [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[c;H0;+0:10]1:[*:11]-[CH2;+0:12]-[N;H0;+0:13](-[*:14])-[*:15]:[c;H0;+0:16]-1:[*:17]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[c;H0;+0:10]1:[*:11]:[cH;+0:12]:[n+;H0:13](-[*:14]):[*:15]:[c;H0;+0:16]:1:[*:17]
Reaction
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Structure and mechanism of sanguinarine reductase, an enzyme of alkaloid detoxification.Vogel M, Lawson M, Sippl W, Conrad U, Roos W2010 Jun 1120378534
Sanguinarine reductase, a key enzyme of benzophenanthridine detoxification.Weiss D, Baumert A, Vogel M, Roos W2006 Feb17080644