EC number:1.3.1.115
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.115 |
|---|---|
| Description: | 3-oxocholoyl-CoA 4-desaturase. |
| Alternative Name: |
3-oxo-choloyl-CoA dehydrogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.115 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.115 |
| KEGG Enzyme Link: | KEGG1.3.1.115 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.115 |
| ExPASy Enzyme Link: | ExPASy1.3.1.115 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.115 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.115 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.115 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.115 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.115 |
EC number:1.3.1.115
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:56664 | 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH2;+0:4]-[*:5].[*:6]-[c;H0;+0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[n+;H0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5].[*:6]-[C;H0;+0:7]1=[CH;+0:13]-[N;H0;+0:11](-[*:12])-[CH;+0:10]=[CH;+0:9]-[CH2;+0:8]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases. | Kang DJ, Ridlon JM, Moore DR 2nd, Barnes S, Hylemon PB | 2008 Jan-Feb | 18047844 |
| RHEA:56660 | 7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH2;+0:4]-[*:5].[*:6]-[c;H0;+0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[n+;H0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5].[*:6]-[C;H0;+0:7]1=[CH;+0:13]-[N;H0;+0:11](-[*:12])-[CH;+0:10]=[CH;+0:9]-[CH2;+0:8]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases. | Kang DJ, Ridlon JM, Moore DR 2nd, Barnes S, Hylemon PB | 2008 Jan-Feb | 18047844 |