EC number:1.3.1.2
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.2 |
|---|---|
| Description: | Dihydropyrimidine dehydrogenase (NADP(+)). |
| Alternative Name: |
Dihydrouracil dehydrogenase (NADP+). Dihydrothymine dehydrogenase. |
| Cath: | 1.10.1060.10; 3.20.20.70; 3.30.70.20; 3.50.50.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.2 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.2 |
| KEGG Enzyme Link: | KEGG1.3.1.2 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.2 |
| ExPASy Enzyme Link: | ExPASy1.3.1.2 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.2 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.2 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.2 |
| RHEA:18093 | 5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[C;H0;+0:10]1-[NH;+0:11]-[C;H0;+0:12](=[*:13])-[CH2;+0:14]-[CH2;+0:15]-[NH;+0:16]-1>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[c;H0;+0:10]1:[nH;+0:11]:[c;H0;+0:12](=[*:13]):[cH;+0:14]:[cH;+0:15]:[nH;+0:16]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Porcine recombinant dihydropyrimidine dehydrogenase: comparison of the spectroscopic and catalytic properties of the wild-type and C671A mutant enzymes. | Rosenbaum K, Jahnke K, Curti B, Hagen WR, Schnackerz KD, Vanoni MA | 1998 Dec 15 | 9860876 |
| Purification and characterization of dihydropyrimidine dehydrogenase from Alcaligenes eutrophus. | Schmitt U, Jahnke K, Rosenbaum K, Cook PF, Schnackerz KD | 1996 Aug 1 | 8806723 |
| Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies. | Podschun B, Jahnke K, Schnackerz KD, Cook PF | 1993 Feb 15 | 8429016 |
| Dihydropyrimidine dehydrogenase. Kinetic mechanism for reduction of uracil by NADPH. | Porter DJ, Spector T | 1993 Sep 15 | 8366081 |
| Purification and properties of dihydrothymine dehydrogenase from rat liver. | Shiotani T, Weber G | 1981 Jan 10 | 7451435 |
| Kinetic mechanism of dihydropyrimidine dehydrogenase from pig liver. | Podschun B, Cook PF, Schnackerz KD | 1990 Aug 5 | 2198281 |
| Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination. | Lohkamp B, Voevodskaya N, Lindqvist Y, Dobritzsch D | 2010 Dec | 20831907 |
| Stereochemistry of NADPH oxidation by dihydropyrimidine dehydrogenase from pig liver. | Podschun B | 1992 Jan 31 | 1734873 |
| A functional analysis of the pyrimidine catabolic pathway in Arabidopsis. | Zrenner R, Riegler H, Marquard CR, Lange PR, Geserick C, Bartosz CE, Chen CT, Slocum RD | 2009 | 19413687 |